A Novel and Efficient Synthesisof Camphorquinone from Camphoric Acid

Qitao Tan; Yunying Wang; Daliang Li; Jiwu Wen; Tianpa You

doi:10.1055/s-2003-41001

SHORTPAPER

A Novel and Efficient Synthesisof Camphorquinone from Camphoric Acid

Qitao Tan, Yunying Wang, Daliang Li, Jiwu Wen, Tianpa You*
Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, 230026, P. R. China
e-Mail: ytp@ustc.edu.cn;

Abstract

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Abstract

Camphorquinone (1), an important finechemical and medicinal product derived from camphor, was efficientlysynthesized from easily available camphoric acid (2).The key steps include acyloin condensation using Me₃SiClas a scavenger of alkoxides and oxidation of the bis(trimethylsilyl)derivative 4 by bromine in CCl₄.The new method offers an efficient alternative synthesis of camphorquinone(1).

Key words

camphor - camphorquinone - cyclization - condensation

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