Bioactive Coumarins from the Leaves of Murraya omphalocarpa

Keh-Shaw Chen; Chin-Chuang Wu; Fang-Rong Chang; Yi-Chen Chia; Michael-Y. Chiang; Wei-Ya Wang; Yang-Chang Wu

doi:10.1055/s-2003-41112

Planta Medica, Table of Contents

Planta Med 2003; 69(7): 654-657
DOI: 10.1055/s-2003-41112

Original Paper

Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Bioactive Coumarins from the Leaves of Murraya omphalocarpa

Keh-Shaw Chen¹ , Chin-Chuang Wu² , Fang-Rong Chang² , Yi-Chen Chia¹ , Michael-Y. Chiang³ , Wei-Ya Wang² , Yang-Chang Wu²

¹Ta-Jen Pharmaceutical Junior College, Ping Tung Hsien, Taiwan, R.O.C
²Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.
³Department of Chemistry, National Sun Yat-Sen University, Kaohsiung, Taiwan, R.O.C.

Abstract

Using antiplatelet aggregation as a guide to fractionation, eight coumarins, omphalocarpinol (1), 5,7-dimethoxy-8-(3′-methyl-2′-oxobutyl)coumarin (2), murralongin, murrayanone, omphamurin (5), murragleinin, mexoticin, and murrangatin, were isolated from the leaves of Murraya omphalocarpa. Compound 1 is new, and 5 is a new enantiomer of omphamurin. The structures of these compounds were elucidated on the basis of spectroscopic techniques, and the structure of compound 1 was confirmed by X-ray crystallographic analysis. Among them, compounds 1, 2 and 5 exhibited significant antiplatelet aggregation activity.

Key words

Murraya omphalocarpa - Rutaceae - antiplatelet aggregation - coumarin - omphalocarpinol

Full Text

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Professor Dr. Yang-Chang Wu

Graduate Institute of Natural Products

Kaohsiung Medical University

Kaohsiung 807

Taiwan

R.O.C

Fax: +886-7-3114773

Email: yachwu@kmu.edu.tw