Perioperative Immunmodulation beim Nierenzellkarzinom - eine Standortbestimmung

Zusammenfassung

Die wesentlichen Therapieoptionen beim Nierenzellkarzinom sind Chirurgie und Immuntherapie. Die Chirurgie geht allerdings mit einer erheblichen perioperativen Immundysfunktion einher. Diese Immundysfunktion kann durch eine Vorbehandlung mit Interleukin-2 (IL-2) moduliert werden, was das tumorspezifische Überleben zu verbessern scheint. Die perioperative Immunmodulation könnte die therapeutische Lücke zwischen neoadjuvanter und adjuvanter Immuntherapie schließen. In diesem Artikel wird die verfügbare Literatur kritisch gesichtet und eigene Originaldaten an 63 Patienten präsentiert.

Abstract

Surgery and immunotherapy are the mainstay in the treatment of renal cell carcinoma. Surgery, however, is associated with considerable perioperative immunodysfunction. This immunodysfunction can be modulated by pretreatment with Interleukin-2 (IL-2), which appears to prolong tumour-specific survival. Perioperative immunomodulation could help close the therapeutic gap between neoadjuvant and adjuvant immunotherapy. This article reviews recent literature and presents original data of 63 patients.

Immunmodulation - perioperativ - Interleukin-2 - Nierentumor

Immunomodulation - perioperative - interleukin-2 - renal cancer

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