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Int J Sports Med 2003; 24(7): 530-534
DOI: 10.1055/s-2003-42010
Nutrition
© Georg Thieme Verlag Stuttgart · New York

Protective Effect of Sesamin Administration on Exercise-Induced Lipid Peroxidation

T.  Ikeda1 , Y.  Nishijima2 , H.  Shibata2 , Y.  Kiso2 , K.  Ohnuki3 , T.  Fushiki1 , T.  Moritani1
  • 1Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan
  • 2Institute for Health Care Science, Suntory Ltd., Osaka, Japan
  • 3Laboratory of Nutrition Chemistry, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan
Further Information

Publication History

Accepted after revision: January 30, 2003

Publication Date:
10 September 2003 (online)

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Abstract

To investigate the mechanism of antioxidative effects of sesamin in vivo, 32 male ddY mice were administered with 10 mg/kg or 100 mg/kg of sesamin (S10, S100), 100 mg/kg of vitamin E (VE100) or control sample (C). They were subjected to 30 min of swimming exercise 2 h after the sample administration by using a new forced-swimming apparatus, i. e. an adjustable-current swimming pool. Exercise resulted in a significant increase in plasma lipid peroxides (LPO) in C and VE100 (p < 0.01), but not in S10 and S100. S100 showed significantly higher total glutathione peroxidase activity and glutathione S-transferase activity in liver compared to C (p < 0.05). In conclusion, sesamin may enhance LPO degradation in the liver resulting in the strong protective effects against exercise-induced plasma lipid peroxidation.

Key words

Glutathione S-transferase - lipid peroxides - sesamin - vitamin E - mice - exercise

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Dr. T. Moritani

Laboratory of Applied Physiology · Graduate School of Human and Environmental Studies

Kyoto University · Sakyo-ku · Kyoto-city · Kyoto 606-8501 · Japan ·

Phone: +81 75 753 6888

Fax: +81 75 753 6888

Email: moritani@virgo.jinkan.kyoto-u.ac.jp