Abstract
To investigate the mechanism of antioxidative effects of sesamin in vivo, 32 male ddY mice were administered with 10 mg/kg or 100 mg/kg of sesamin (S10, S100), 100 mg/kg of vitamin E (VE100) or control sample (C). They were subjected to 30 min of swimming exercise 2 h after the sample administration by using a new forced-swimming apparatus, i. e. an adjustable-current swimming pool. Exercise resulted in a significant increase in plasma lipid peroxides (LPO) in C and VE100 (p < 0.01), but not in S10 and S100. S100 showed significantly higher total glutathione peroxidase activity and glutathione S-transferase activity in liver compared to C (p < 0.05). In conclusion, sesamin may enhance LPO degradation in the liver resulting in the strong protective effects against exercise-induced plasma lipid peroxidation.
Key words
Glutathione S-transferase - lipid peroxides - sesamin - vitamin E - mice - exercise
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Dr. T. Moritani
Laboratory of Applied Physiology · Graduate School of Human and Environmental Studies
Kyoto University · Sakyo-ku · Kyoto-city · Kyoto 606-8501 · Japan ·
Phone: +81 75 753 6888
Fax: +81 75 753 6888
Email: moritani@virgo.jinkan.kyoto-u.ac.jp
