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Synthesis 2003(16): 2503-2506
DOI: 10.1055/s-2003-42436
DOI: 10.1055/s-2003-42436
PAPER
© Georg Thieme Verlag Stuttgart · New York
Scandium(III) Triflate as an Efficient and Recyclable Catalyst for Chemoselective Conversion of Carbonyl Compounds to 1,3-Oxathiolanes
Further Information
Received
17 March 2003
Publication Date:
23 October 2003 (online)
Publication History
Publication Date:
23 October 2003 (online)
Abstract
A variety of carbonyl compounds can be easily and rapidly converted to the corresponding 1,3-oxathiolanes in the presence of a catalytic amount of scandium(III) triflate [Sc(OTf)3] in CH2Cl2. After completion of the reaction, the catalyst can straightforwardly be recovered using standard methods. Moreover, by employing this protocol, chemoselective oxathioacetalization of aldehydes in the presence of ketones can be achieved.
Key words
heterocycles - protecting groups - acetals - - scandium - aldehydes - ketones - catalysis
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