A Facile Synthesis of AICAR from Inosine

Naoki Kohyama; Yukio Yamamoto

doi:10.1055/s-2003-42455

PAPER

A Facile Synthesis of AICAR from Inosine

Naoki Kohyama, Yukio Yamamoto*
Graduate School of Human and Environmental Studies, Kyoto University, Sakyo-ku, Yoshida, Kyoto 606-8501, Japan
Fax: +81(75)7536833; e-Mail: yukio@fischer.jinkan.kyoto-u.ac.jp;

Abstract

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Abstract

5-Amino-1-β-d-ribofuranosylimidazole-4-carboxamide (AICAR; 1) (Figure [1] ) was efficiently prepared from inosine through its 1-alkoxymethylderivatives. The stability of these derivatives enabled their purification by column chromatography (silica gel). The operation ensured the high quality of 1, which was obtained in good yield through alkaline hydrolysis of the derivatives.

Key words

furans - inosine - nucleosides - hydrolyses - ring opening

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References

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