A New and Facile Iodine(III)-Mediated Approach for the Regioselective Alkoxylation of 2,5-Dihydroxyacetophenone

Abstract

Oxidation of 2,5-dihydroxyacetophenone with iodobenzene diacetate (IBD) in different alcohols leads to regioselective alkoxylation, thereby providing a new and convenient route for the synthesis of 6-alkoxy-2,5-dihydroxyacetophenones.

Key words

hypervalent iodine - regioselective alkoxylation - 2,5-dihydroxyacetophenone - iodobenzene diacetate - oxidations

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9

There was no significant increase in the yields by running the reaction for longer time or by adding more IBD.