Stereoselective Total Synthesis of (+)-Virol C

Abstract

A highly stereoselective synthesis of (+)-Virol C (1) has been achieved starting from octan-1-ol (6) using two different strategies, elimination reactions of epoxyallyl chloride 12 and epoxy chloride 16 to hydroxyenyne 2 and trans-hydroxyalkenyl chloride 4 as key reactions in route a and route b, respectively.

Key words

Virol C - stereoselective - elimination reaction - Cadiot-Chodkiewicz coupling - Sonogashira

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