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Planta Med 2003; 69(9): 867-868
DOI: 10.1055/s-2003-43224
Letter
© Georg Thieme Verlag Stuttgart · New York

Cytotoxic and DNA Damaging Activity of Some Aporphine Alkaloids from Stephania dinklagei

Ahmet C. Gören1 , 2 , Bing-Nan Zhou2 , David G. I. Kingston2
  • 1Tubitak Marmara Research Center, Materials and Chemical Technologies Research Institute, Gebze-Kocaeli, Turkey
  • 2Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA
Further Information

Publication History

Received: February 7, 2003

Accepted: May 3, 2003

Publication Date:
04 November 2003 (online)

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Abstract

Six aporphine alkaloids, liriodenine, corydine, isocorydine, atherospermidine, stephalagine and dehydrostephalagine, were isolated by bioassay-guided fractionation of the EtOH extract of the stems of Stephania dinklagei. Liriodenine showed strong cytotoxic activity while corydine and atherospermidine showed DNA damaging activity. Dehydrostephalagine and atherospermidine were isolated from this plant for the first time.

References

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Dr. Ahmet C. Gören

TUBITAK, Marmara Research Center

Materials and Chemical Technologies Research Institute

P.O. Box.21

41470 Gebze-Kocaeli

Turkey

Fax: +90-262-6795001

Email: ahmet.goren@ume. tubitak.gov.tr