Download PDF
Skull Base 2003; 13(3): 167-172
DOI: 10.1055/s-2003-43327
CASE REPORT

Copyright © 2003 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Skull Base Plasmacytoma in a Patient with Light Chain Myeloma

Zeki Ustuner1 , Mert Basaran1 , Talat Kiris2 , Bilge Bilgic3 , Serra Sencer4 , Burak Sakar1 , Yavuz Dizdar1 , Sevil Bavbek1 , Haluk Onat1 , Randall W. Porter
  • 1Institute of Oncology
  • 2Istanbul Medical Faculty, Department of Neurosurgery, Istanbul University, Istanbul, Turkey
  • 3Istanbul Medical Faculty, Department of Pathology, Istanbul University, Istanbul, Turkey
  • 4Istanbul Medical Faculty, Department of Radiology, Istanbul University, Istanbul, Turkey
Further Information

Publication History

Publication Date:
18 May 2004 (online)

    Permissions and Reprints

ABSTRACT

Skull base involvement of plasmacytoma is reported in a patient with light chain myeloma. A 39-year-old man was admitted after experiencing paresthesia on the left side of the face and left arm, intermittent diplopia, and hoarseness for 2 years. Cranial magnetic resonance imaging revealed a large midline mass extending from the middle and posterior skull base into the upper two cervical vertebrae. An extramedullary plasmacytoma associated with light chain multiple myeloma was diagnosed after biopsy of the mass and laboratory investigations. The imaging findings and clinical features associated with this rare site of extramedullary plasmacytoma involvement are reported.

KEYWORDS

Skull base - multiple myeloma - light chain - plasmacytoma

REFERENCES

  • 1 Nofsinger Y C, Mirza N, Rowan P T, Lanza D, Weinstein G. Head and neck manifestations of plasma cell neoplasms.  Laryngoscope . 1997;  107 741-746
    CrossrefPubMedGoogle Scholar
  • 2 Marais J, Brookes G B, Lee C C. Solitary plasmacytoma of the skull base.  Ann Otol Rhinol Laryngol . 1992;  101 665-668
    PubMedGoogle Scholar
  • 3 Kanemura N, Tsurumi H, Hara T, Yamada T, Sawada M, Moriwaki H. Multiple myeloma complicated by bilateral abducens nerve palsy due to a tumor in the clivus.  Rinsho Ketsueki . 2001;  42 218-220
    PubMedGoogle Scholar
  • 4 Movsas T Z, Balcer L J, Eggenberger E R, Hess J L, Galetta S L. Sixth nerve palsy as a presenting sign of intracranial plasmacytoma and multiple myeloma.  J Neuroophthalmol . 2000;  20 242-245
    CrossrefPubMedGoogle Scholar
  • 5 Hogan M C, Lee A, Solberg L A, Thome S D. Unusual presentation of multiple myeloma with unilateral visual loss and numb chin syndrome in a young adult.  Am J Hematol . 2002;  70 55-59
    CrossrefPubMedGoogle Scholar
  • 6 Munshi N C, Tricot G, Barlogie B. Plasma cell neoplasms. In: Devita VT, Hellman S, Rosenberg SA, eds. Cancer Principles and Practice of Oncology 6th ed. Philadelphia, PA: Lippincott Williams-Wilkins Pub Inc; 2001: 2465-2499
    Google Scholar
  • 7 Vijaya-Sekaran S, Delap T, Abramovich S. Solitary plasmacytoma of the skull base presenting with unilateral sensorineural hearing loss.  J Laryngol Otol . 1999;  113 164-166
    PubMedGoogle Scholar
  • 8 Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 21-1992. A 65-year-old man with a mass that involved the base of the skull.  N Engl J Med . 1992;  326 1417-1424
    PubMedGoogle Scholar
  • 9 Corwin J, Lindberg R D. Solitary plasmacytoma of bone versus extramedullary plasmacytoma and their relationship to multiple myeloma.  Cancer . 1979;  43 1007-1013
    CrossrefPubMedGoogle Scholar
  • 10 Bindal A K, Bindal R K, van Loveren H, Sawaya R. Management of intracranial plasmacytoma.  J Neurosurg . 1995;  83 218-221
    CrossrefPubMedGoogle Scholar