Reduziertes Pankreatitisrisiko nach endoskopischer Mikrotransducer Manometrie des Sphinkter Oddi: Ein randomisierter Vergleich mit der Perfusionsmanometrie-Technik

Zusammenfassung

Mikrotransducer-Manometrie des Sphinkter-Oddi ist eine akzeptable Alternative zur Perfusionsmanometrie in der Beurteilung der motorischen Shinkter-Oddi-Funktion. Sie vermeidet die Volumenbelastung des biliopankreatischen Systems und könnte deshalb mit einem verminderten Pankreatitisrisiko nach manometrischer Untersuchung verbunden sein.
Während einer 2-Jahres-Periode wurde bei 215 Patienten eine Mikrotransducer-Manometrie des Sphinkter-Oddi als alleinige Untersuchung durchgeführt. Die Pankreatitishäufigkeit wurde prospektiv erfasst. Sie betrug insgesamt 4,2 % (9 Fälle: 6 leichte, 2 mittelschwere und 1 schwerer Verlauf, kein Todesfall, keine Operation). In der randomisierten Studie an 130 Patienten betrug die Pankreatitisfrequenz nach Mikrotransducer-Manometrie 3,1 % und nach Perfusionsmanometrie 13,8 % (p = 0,05), so dass die endoskopische Mikrotransducer-Manometrie des Sphinkter-Oddi mit einem geringeren Pankreatitisrisiko verbunden ist als die Perfusionsmanometrie.

Abstract

Endoscopic microtransducer manometry of the sphincter of Oddi has been shown to be a reliable alternative to perfusion manometry for evaluating sphincter of Oddi motor function. It avoids volume loading of the biliopancreatic system, and may therefore be associated with al lower risk of inducing postmanometry pancreatitis. During a 2-year period, microtransducer meanometry of the sphincter of Oddi was carried out in 215 patients as the sole procedure in all. The frequency of pancreatitis was assessed prospectively. During the 2-year period, nine cases of pancreatitis (a pancreatitis frequency of 4.2 %) were observed after microtransducer manometry, and most were of mild degree (six mild, two moderate, and one severe). No deaths occurred, and no surgical procedures were required.
In the randomised part of the study. The frequency of pancreatitis after microtransducer manometry was 3.1 %, compared with 13.8 % after perfusion manometry (< 0.05).
In Endoscopic microtransducer manometry of the sphincter of Oddi is associated with a lower risk for postmanometry panfreatitis than standard perfusion manometry.

Sphinkter-Oddi - Pankreatitis - Manometrie - Mikrotransducer

Sphincter of Oddi - pancreatitis - manometry - microtransducer

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