The First Total Synthesis of the Antimicrobial Sesquiterpenes (±)-Enokipodins A and B

Abstract

Efficient first total synthesis of antimicrobial sesquiterpenes enokipodins A and B (1 and 2, respectively) and formal total synthesis of cuparene-1,4-diol (5) and cuparene-1,4-quinone (7) have been accomplished starting from 2,5-dimethoxy-4-methyl­acetophenone employing Claisen rearrangement and ring-closing metathesis reaction as key steps.

Key words

sesquiterpenes - enokipodins A and B - ring-closing metathesis - Claisen rearrangement

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