Efficient first total synthesis of antimicrobial sesquiterpenes enokipodins A and B (1 and 2, respectively) and formal total synthesis of cuparene-1,4-diol (5) and cuparene-1,4-quinone (7) have been accomplished starting from 2,5-dimethoxy-4-methylacetophenone employing Claisen rearrangement and ring-closing metathesis reaction as key steps.
sesquiterpenes - enokipodins A and B - ring-closing metathesis - Claisen rearrangement
