Rationale and Effects of the Administration of Antioxidants in Critically Ill Patients

Zusammenfassung

Der erhöhte oxidative Stress bei lebensgefährlich erkrankten Patienten könnte bei der Pathogenese vielfachen Organversagens eine pathophysiologische Rolle spielen, worauf neuere klinisch therapeutische Studien mit Antioxidanzien hinzuweisen scheinen. Eine prophylaktische Verabreichung antioxidativer Vitamine oder Glutamine als Bestandteile einer unterstützenden Ernährung, oder getrennt verordnet, setzt den oxidativen Stress wirksam herab und vermindert - wie einige Studien zeigten - das Auftreten von Organversagen und bewirkt eine Besserung des Zustandes lebensgefährlich Erkrankter und damit ihrer Überlebenschancen. Patienten, bei denen die Gefahr eines Organversagens vorliegt, könnte bei rechtzeitiger Verabreichung von Antioxidanzien, einschließlich Vitaminen und Glutaminen, ein günstigerer Verlauf der Behandlung ermöglicht werden.

Abstract

The increased oxidative stress in critically ill patients could exert pathophysiological role in the pathogenesis of multiple organ failures, as suggested by recent clinical trials of antioxidant therapies. Prophylactic administration of antioxidant vitamins or glutamine, incorporated in the nutritional support or given as separate medications, efficiently attenuates the oxidative stress and in some studies, decreases the incidence of organ failures and ultimately improves the outcome of critically ill patients. Patients at risk of organ failures could benefit from the early adjunction of antioxidant treatment, including vitamins and glutamine.

Oxidativer Stress - Nährstoffbedarf - Vitamin A - Vitamin C - Vitamin E

Oxidative stress - nutritional support - vitamin A - ascorbic acid - vitamin E

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