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Thorac Cardiovasc Surg 2004; 52(3): 152-158
DOI: 10.1055/s-2004-817981
Original Cardiovascular

© Georg Thieme Verlag KG Stuttgart · New York

CABG and Bone Marrow Stem Cell Transplantation after Myocardial Infarction[*]

C. Stamm1 , H.-D. Kleine2 , B. Westphal1 , M. Petzsch3 , C. Kittner4 , C. A. Nienaber3 , M. Freund2 , G. Steinhoff1
  • 1Department of Cardiac Surgery, University of Rostock, Rostock, Germany
  • 2Department of Hematology and Oncology, University of Rostock, Rostock, Germany
  • 3Department of Cardiology, University of Rostock, Rostock, Germany
  • 4Department of Radiology, University of Rostock, Rostock, Germany
Further Information

Publication History

Received April 23, 2003

Publication Date:
11 June 2004 (online)

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Abstract

Objective: Bone marrow-derived adult stem cells may be able to regenerate infarcted myocardium. We initiated a phase-I study of autologous stem cell transplantation in patients undergoing coronary artery bypass grafting. Methods: Inclusion criteria were: acute myocardial infarction > 10 days ago; presence of a distinct area of infarcted and akinetic myocardium; CABG indicated to treat ischemia of other LV wall areas. Stem cells were isolated from bone marrow using a ferrite-conjugated AC133 antibody, and were injected in the infarct border zone during the CABG operation. Results: To date, 12 patients were treated without major complications. There is no evidence of new ventricular arrhythmia or neoplasia. Scintigraphic imaging demonstrated significantly improved local perfusion in the stem cell-treated infarct area. LV dimensions (LVEDV 140 ± 38 ml vs. 124 ± 30 ml, p = 0.004, paired t-test) and LV ejection fraction (39.7 ± 9 % vs. 48.7 ± 6 %, p = 0.007) have improved. Conclusions: Bone marrow stem cell transplantation for myocardial regeneration can be safely performed in humans. There is evidence of improved revascularization and contractility of infarct areas, but controlled studies are needed to clearly determine the clinical benefit.

Key words

Myocardial infarction - coronary artery bypass - stem cells - AC133 - angiogenesis

1 Presented at the 32nd Annual Meeting of the German Society for Thoracic and Cardiovascular Surgery, Leipzig, February 26, 2003

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1 Presented at the 32nd Annual Meeting of the German Society for Thoracic and Cardiovascular Surgery, Leipzig, February 26, 2003

Prof. Dr. Gustav Steinhoff

Universität Rostock
Klinik für Herzchirurgie

Schillingallee 35

18057 Rostock

Germany

Phone: + 493814946101

Fax: + 49 38 14 94 61 02

Email: gustav.steinhoff@med.uni-rostock.de