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Planta Med 2004; 70(4): 334-341
DOI: 10.1055/s-2004-818945
Original Paper
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Effects of Quercetin Treatment on Vascular Function in Deoxycorticosterone Acetate-Salt Hypertensive Rats. Comparative Study with Verapamil

Milagros Galisteo1 , 3 , María Francisca García-Saura1 , 3 , Rosario Jiménez1 , Inmaculada Concepción Villar1 , Rosemary Wangensteen2 , Antonio Zarzuelo1 , Félix Vargas2 , Juan Duarte1
  • 1Department of Pharmacology, School of Pharmacy, University of Granada, Granada, Spain
  • 2Department of Physiology, School of Medicine, University of Granada, Granada, Spain
  • 3M. Galisteo and M. F. García-Saura contributed equally to this work
This work was supported by CICYT (SAF 98 - 0160, SAF-2001 - 2953) Grants. M. Galisteo was recipient of a research grant from the University of Granada (Spain)
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Publikationsverlauf

Received: September 10, 2003

Accepted: January 25, 2004

Publikationsdatum:
19. April 2004 (online)

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Abstract

This study analysed and compared the effects of chronic oral treatment with quercetin or verapamil on systolic blood pressure and vascular function in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Quercetin and verapamil inhibited the development of DOCA-salt-induced hypertension in a similar manner. DOCA-salt-hypertensive rats showed potassium depletion and oxidative stress, prevented only by concomitant quercetin administration. Quercetin and verapamil treatments reduced the endothelium-independent hyper-reactivity to KCl observed in the aorta of DOCA-salt-hypertensive rats, but only quercetin increased the contractile responses to angiotensin II, improved endothelial dysfunction and restored basal aortic Cu/Zn SOD expression, altered in DOCA-salt-treated rats. In conclusion, quercetin and verapamil show similar antihypertensive effects in mineralocorticoid hypertension, but quercetin was superior to verapamil in improving endothelial-dependent aortic dilatation, suggesting a better vascular protection in this volume expansion hypertension model.

Key words

Quercetin - verapamil - mineralocorticoid hypertension - antioxidant - vascular reactivity - endothelial dysfunction

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J. Duarte

Dept. Farmacología

Fac. Farmacia

Universidad de Granada

18071 Granada

Spain

Telefon: +34-958-243-889

Fax: +34-958-248-964

eMail: jmduarte@ugr.es