Attenuated ANF Response to Exercise in Athletes with Exercise-Induced Hypoxemia

F. Durand; P. Mucci; M. Hayot; I. Couret; A. Bonnardet; Ch. Préfaut

doi:10.1055/s-2004-819934

International Journal of Sports Medicine, Table of Contents

Int J Sports Med 2004; 25(4): 252-256
DOI: 10.1055/s-2004-819934

Physiology & Biochemistry

Attenuated ANF Response to Exercise in Athletes with Exercise-Induced Hypoxemia

F. Durand^1, ² , P. Mucci³ , M. Hayot² , I. Couret⁴ , A. Bonnardet⁵ , Ch. Préfaut²

¹Laboratoire Sport, Santé, Altitude, Département STAPS, Font-Romeu, France
²Laboratoire de Physiologie des Interactions, Hôpital A. de Villeneuve, Montpellier, France
³Laboratoire d’Analyse Multidisciplinaire des Pratiques Sportives, U.F.R.S.T.A.P.S. Liévin, France
⁴Service Central de Médecine Nucléaire, Hôpital Lapeyronie, Montpellier, France
⁵Service de Biochimie, Hôpital Lapeyronie, Montpellier, France

Abstract

Some highly trained endurance athletes develop an exercise-induced hypoxemia (EIH) at least partially due to a hemodynamic factor with a potential stress failure on pulmonary capillaries. Atrial natriuretic factor (ANF) is a pulmonary vasodilatator and its release during exercise could be reduced with endurance training. We hypothesized that athletes exhibiting EIH, who have a greater training volume than non-EIH athletes, have a reduced ANF release during exercise explaining the pathophysiology of EIH. Ten highly trained EIH-athletes (HT-EIH), ten without EIH (HT-nEIH), and nine untrained (UT) males performed incremental exercise to exhaustion. No between group differences occurred in resting ANF plasma levels. In contrast to HT-nEIH and UT (p < 0.05), HT-EIH showed a smaller increase in ANF concentration between rest and maximal exercise (HT-EIH: 8.12 ± 0.69 vs. 14.1 ± 1.86 pmol × l^-1; HT-nEIH: 10.46 ± 1 vs. 18.7 ± 1.8 pmol × l^-1; UT: 6.23 ± 0.95 vs. 20.38 ± 2.79 pmol × l^-1). During the recovery, ANF levels decreased significantly in HT-nEIH and UT groups (p < 0.05). Electrolyte values increased in all groups during exercise but were higher in both trained groups. In conclusion, this study suggested that ANF response to exercise may be important for exercise-induced hypoxemia.

Key words

Exercise-induced hypoxemia - atrial natriuretic factor - gas exchange

Full Text

References

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F. Durand

Laboratoire Sport Santé Altitude · Département STAPS

66120 Font-Romeu · France

Phone: +33 468 308 074

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