Thorac Cardiovasc Surg 2004; 52(4): 206-210
DOI: 10.1055/s-2004-821075
Original Thoracic

© Georg Thieme Verlag KG Stuttgart · New York

Outcome of Surgery for Small Cell Lung Cancer - Response to Induction Chemotherapy Predicts Survival

H. Nakamura1 , 2 , Y. Kato2 , H. Kato2
  • 1Department of Respiratory Surgery, International University of Health and Welfare Atami Hospital, Shizuoka, Japan
  • 2Department of Surgery, Tokyo Medical University Hospital, Tokyo, Japan
Weitere Informationen

Publikationsverlauf

Received January 5, 2004

Publikationsdatum:
04. August 2004 (online)

Preview

Abstract

Background: The role of surgery for local control of small cell lung cancer (SCLC) is controversial. Methods: Sixty-nine consecutive patients who underwent complete resection of SCLC in our hospital were reviewed. The patients included 62 men and 7 women. Clinical stage at the time of diagnosis was c-stages IA and B in 29, c-stages IIA and B in 12, c-stage IIIA in 21, and c-stage IIIB in 7. Results: Thirty-two patients received induction chemotherapy, and 37 patients underwent initial surgery. The overall response rate to induction chemotherapy was 71.9 %. The survival rate stratified by clinical stage at the time of diagnosis was 48.9 % for c-stage I, 33.3 % for c-stage II, 20.2 % for c-stage IIIA, and 0 % for c-stage IIIB. Downstaging after induction chemotherapy conferred a survival benefit. Survival after lobectomy or bilobectomy was better than after pneumonectomy. Patients who received adjuvant chemotherapy survived longer than patients who did not. Conclusions: Surgery combined with chemotherapy is a therapeutic option in selected patients with SCLC. Pathologic nodal status and response to induction chemotherapy are predictors of survival.

References

M. D., PhD Haruhiko Nakamura

Department of Respiratory Surgery
International University of Health and Welfare Atami Hospital

13-1 Higashikaigan-cho

Atami-City Shizuoka 413-0012

Japan

Telefon: 2906

Fax: + 81 5 57 83 66 32

eMail: h.nakamura@iuhw.ac.jp