‘One-Pot’ Synthesis of Chiral N-Protected α-Amino Acid-Derived 1,2,4-Oxadiazoles

Antonio L. Braga; Diogo S. Lüdtke; Eduardo E. Alberto; Luciano Dornelles; Wolmar A. Severo Filho; Valeriano A. Corbellini; Daiane M. Rosa; Ricardo S. Schwab

doi:10.1055/s-2004-822391

PAPER

‘One-Pot’ Synthesis of Chiral N-Protected α-Amino Acid-Derived 1,2,4-Oxadiazoles

Antonio L. Braga*^a, Diogo S. Lüdtke^a, Eduardo E. Alberto^a, Luciano Dornelles*^b, Wolmar A. Severo Filho^b, Valeriano A. Corbellini^b, Daiane M. Rosa^b, Ricardo S. Schwab^b
^a Departamento de Química, Universidade Federal de Santa Maria, 97105-900, Santa Maria, RS, Brazil
Fax: +55(55)2208031; e-Mail: albraga@quimica.ufsm.br;
^b Departamento de Química e Física, Universidade de Santa Cruz do Sul, 96815-900, Santa Cruz do Sul, RS, Brazil
e-Mail: luciano@unisc.br;

Abstract

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Abstract

A series of α-amino acid-derived 1,2,4-oxadiazoles have been synthesized via an easy, inexpensive and one-pot protocol. The heterocycles were obtained in good yields and in relatively short reaction times.

Key words

amino acids - oxadiazoles - heterocycles

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References

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