Zentralbl Gynakol 2004; 126(3): 138-147
DOI: 10.1055/s-2004-822694
Übersicht

© Georg Thieme Verlag Stuttgart · New York

Komplementärmedizin, Phytotherapie und Sojaisoflavone als Phytoöstrogene

Complementary Medicine: Phytotherapy and Soyaisoflavones as PhytoestrogensJ. Melzer1 , R. Brignoli2 , R. Saller1
  • 1Universitätsspital Zürich, Departement Innere Medizin, Abteilung Naturheilkunde, Zürich, Schweiz
  • 2Tradyser Consult GmbH, Rüschlikon, Schweiz
Further Information

Publication History

Publication Date:
05 July 2004 (online)

Zusammenfassung

Nach einer kurzen Einführung in die Thematik Komplementärmedizin/Naturheilkunde und Phytotherapie erfolgt ein Überblick über Sojaisoflavone als Phytoöstrogene. Im deutschsprachigen Raum haben Begriff und Fach Naturheilkunde eine 150-jährige Tradition an Theorienbildung und Praxis in Laien- und medizinischen Fachkreisen. Der Begriff Komplementärmedizin wird hingegen seit rund 15 Jahren in englischsprachigen Ländern benutzt und etabliert sich als Sammelbegriff für eine Fülle kulturell und qualitativ unterschiedlicher medizinischer Methoden und Verfahren, die die Schulmedizin ergänzen können. Einer der ältesten und intensiv beforschten therapeutischen Bereiche der europäischen Naturheilkunde und der außereuropäischen Komplementärmedizin ist die Phytotherapie. Am Beispiel der Sojaisoflavone zeigen sich Unterschiede zwischen der auf Vielstoffgemischen basierenden Phytotherapie und der meist auf isolierten Monosubstanzen basierenden Supplemente (neutraceuticals) von Phytoöstrogenen. Die verschiedenen Präparate von Sojaisoflavonen sind keine Phytotherapeutika. Ein Überblick zur experimentellen und klinischen Datenlage über die Phytoöstrogengruppe der Sojaisoflavone zur Prävention maligner Erkrankungen, klimakterischer Beschwerden (z. B. Hitzewallungen, Schweißausbrüche), Osteoporose oder kardiovaskulärer Erkrankungen weist darauf hin, dass der Verzehr von phytoöstrogenhaltigen Nahrungsmitteln vermutlich gesundheitsförderlich, aber der gesundheitliche Nutzen der Supplementierung isolierter Phytoöstrogene noch nicht ausreichend belegt ist.

Abstract

After a introduction concerning complementary medicine, naturopathy and phytotherapy a general view of soy isoflavones as phytoestrogens will be given. In german speaking countries the term and topic naturopathy has a tradition of 150 years regarding theoretical development and practical use among lay people and health professionals in European culture. In contrary the term complementary medicine has been used for approximately 15 years in englisch speaking countries as a kind of collective name for European and Non-European medical cultures and traditions. Complementay medicine summarizes a huge variety of cultural, medical and qualitywise different medical methods and treatments which can be a contribution to conventional medicine. One of the oldest and intensly researched fields in European and Non-European complementary medicine is the use of herbal drugs (phytotherapy). Soy isoflavones serve as an example to show the differences between phytotherapy based on multicompounds and dietary supplements (neutraceuticals) based on monosubstances. The differing preparations of soy isoflavones are not phytotherapeutic medicine. A review of the experimental and clinical data concerning soy isoflavones as phytoestrogens for the prevention of cancer, menopausal complaints, osteoporosis or cardiovascular diseases indicates that the consumption of food containing phytoestrogens seems to be health protective. Yet, the relevance of supplementation of single phytoestrogens for an additional health effect is not sufficiently proven.

Literatur

  • 1 Institut für Demoskopie . Wachsendes Vertrauen in Naturheilmittel.  Deutsches Ärzteblatt. 1997;  94 C1857-C1858
  • 2 Institut für Demoskopie .Naturheilmittel 2002.  http://www.bah-bonn.de/news/Naturheilmittel.pdf
  • 3 Jenny S, Simon M, Meier B. Haltung der Bevölkerung gegenüber Komplementärmedizin. Eine repräsentative Befragung in der Schweiz im Auftrag der Forschungsstiftung Komplementärmedizin.  Schweizerische Zeitschrift für GanzheitsMedizin. 2002;  14 340-347
  • 4 European Commission .Cost Action B 4. Unconventional medicine. Final report of the management commitee 1993-98. Office for Official Publications of the European Communities, Luxembourg 1998
  • 5 Saller R, Kristof O. Einführung. In: Saller R, Bachmann R (Hrsg). Naturheilverfahren und Komplementärmedizin in der Praxis. Spitta, Balingen 1998; 1-56
  • 6 Linde K, ter Riet G, Hondras M, Vickers A, Saller R, Melchart D. Systematic Reviews of Herbal Medicines - an Annotated Bibliography.  Forsch Komplementärmed Klass Naturheilkd. 2003;  10 (Suppl 1) 17-27
  • 7 Saller R, Reichling J, Hellenbrecht D. Phytotherapie. Haug, Heidelberg 1995
  • 8 Reichling J, Hostanska K, Saller R. Johanniskraut (Hypericum perforatum L.) - Vielstoffgemisch kontra phytogene Einzelstoffe.  Forsch Komplementärmed Klass Naturheilkd. 2003;  10 (Suppl 1) 28-32
  • 9 Saller R. Phytotherapie und therapeutisch orientierte Forschung. In: Saller R, Feiereis H (Hrsg). Erweiterte Schulmedizin. Bd. 1. Beiträge zur Phytotherapie. Hans Marseille, München 1993; 13-34
  • 10 Saller R, Melzer J, Reichling J. Johanniskraut (Hypericum perforatum): Ein plurivalenter Rohstoff für traditionelle und moderne Therapien.  Forsch Komplementärmed Klass Naturheilkd. 2003;  10 (Suppl 1) 33-40
  • 11 Hostanska K, Reichling J, Bommer S, Weber M, Saller R. Aequeous ethanolic extract of St. John's Wort (Hypericum perforatum L.) induces growth inhibition and apoptosis in human malignant cells in vitro.  Pharmazie. 2002;  57 323-331
  • 12 Schellenberg R. Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomised, placebo controlled study.  BMJ. 2001;  322 134-137
  • 13 Borrelli F, Ernst E. Cimicifuga racemosa: a systematic review of its clinical efficacy.  Eur J Clin Pharmacol. 2002;  58 235-241
  • 14 Ashikaga T, Bosompra K, O'Brien P, Nelson L. Use of complimentary and alternative medicine by breast cancer patients: prevalence, patterns and communication with physicians.  Support Care Cancer. 2002;  10 542-548
  • 15 Lengacher C A, Bennett M P, Kip K E, Keller R, LaVance M S, Smith L S, Cox C E. Frequency of use of complementary and alternative medicine in women with breast cancer.  Oncol Nurs Forum. 2002;  29 1445-1452
  • 16 Tasaki K, Maskarinec G, Shumay D M, Tatsumura Y, Kakai H. Communication between physicians and cancer patients about complementary and alternative medicine: exploring patients' perspectives.  Psychooncology. 2002;  11 212-220
  • 17 Kulling S E, Watzel B. Phytoöstrogene.  Ernährungs-Umschau. 2003;  50 234-239
  • 18 Beck V, Unterrieder E, Krenn L, Kubelka W, Jungbauer A. Comparison of hormonal activity (estrogen, androgen and progestin) of standardized plant extracts for large scale use in hormone replacement therapy.  J Steroid Biochem Mol Biol. 2003;  84 259-268
  • 19 Fitzpatrick L A. Soy isoflavones: hope or hype?.  Maturitas. 2003;  44 (Suppl 1) 21-29
  • 20 Wuttke W, Jarry H, Westphalen S, Christoffel V, Seidlova-Wuttke D. Phytoestrogens for hormone replacement therapy?.  J Steroid Biochem Mol Biol. 2003;  83 133-147
  • 21 Setchell K D. Soy isoflavones-benefits and risks from nature's selective estrogen receptor modulators (SERMs).  J Am Coll Nutr. 2001;  20 (Suppl 5) 354-362
  • 22 Ursin G, Wu A H, Hoover R N, West D W, Nomura A M, Kolonel L N, Pike M C, Ziegler R G. Breast cancer and oral contraceptive use in Asian-American women.  Am J Epidemiol. 1999;  150 561-567
  • 23 Ziegler R G, Hoover R N, Pike M C, Hildesheim A, Nomura A M, West D W, Wu-Williams A H, Kolonel L N, Horn-Ross P L, Rosenthal J F. et al . Migration patterns and breast cancer risk in Asian-American women.  J Natl Cancer Inst. 1993;  85 1819-1827
  • 24 Shimizu H, Ross R K, Bernstein L, Yatani R, Henderson B E, Mack T M. Cancers of the prostate and breast among Japanese and white immigrants in Los Angeles County.  Br J Cancer. 1991;  63 963-966
  • 25 Kantoff P W. Section 12 IX PROSTATE CANCER Epidemiology Scientific American Medicine. WebMed, December 2000
  • 26 Stephens F O. The rising incidence of breast cancer in women and prostate cancer in men. Dietary influences: a possible preventive role for nature's sex hormone modifiers - the phytoestrogens.  Oncol Rep. 1999;  6 865-870
  • 27 Robertson T L, Kato H, Rhoads G G, Kagan A, Marmot M, Syme S L, Gordon T, Worth R M, Belsky J L, Dock D S, Miyanishi M, Kawamoto S. Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California. Incidence of myocardial infarction and death from coronary heart disease.  Am J Cardiol. 1977;  39 239-243
  • 28 Rubia M, Marcos I, Muennig P A. Increased risk of heart disease and stroke among foreign-born females residing in the United States.  Am J Prev Med. 2002;  22 30-35
  • 29 American College of Obstetricians and Gynecologists Committee on Practice Bulletins-Gynecology . ACOG Practice Bulletin. Clinical Management Guidelines for Obstetrician-Gynecologists. Use of botanicals for management of menopausal symptoms.  Obstet Gynecol. 2001;  97 (Suppl) 1-11
  • 30 Fletcher R J. Food sources of phyto-oestrogens and their precursors in Europe.  Br J Nutr. 2003;  89 (Suppl 1) 39-43
  • 31 Murkies A, Dalais F S, Briganti E M, Burger H G, Healy D L, Wahlqvist M L, Davis S R. Phytoestrogens and breast cancer in postmenopausal women: a case control study.  Menopause. 2000;  7 289-296
  • 32 Fruchter R G, Nayeri K, Remy J C, Wright C, Feldman J G, Boyce J G, Burnett W S. Cervix and breast cancer incidence in immigrant Caribbean women.  Am J Public Health. 1990;  80 722-724
  • 33 Kliewer E V, Smith K R. Breast cancer mortality among immigrants in Australia and Canada.  J Natl Cancer Inst. 1995;  87 1154-1161
  • 34 Mishra S I, Dickerson V, Najm W. Phytoestrogens and breast cancer prevention: What is the evidence?.  Am J Obstet Gynecol. 2003;  188 (Suppl 5) 66-70
  • 35 Sirtori C R. Risks and benefits of soy phytoestrogens in cardiovascular diseases, cancer, climacteric symptoms and osteoporosis.  Drug Saf. 2001;  24 665-682
  • 36 Kulling S E, Rosenberg B, Jacobs E, Metzler M. The phytoestrogens coumoestrol and genistein induce structural chromosomal aberrations in cultured human peripheral blood lymphocytes.  Arch Toxicol. 1999;  73 50-54
  • 37 Mitchell J H, Duthie S J, Collins A R. Effects of phytoestrogens on growth and DNA integrity in human prostate tumor cell lines: PC-3 and LNCaP.  Nutr Cancer. 2000;  38 223-228
  • 38 Bartholomew R M, Ryan D S. Lack of mutagenicity of some phytoestrogens in the salmonella/mammalian microsome assay.  Mutat Res. 1980;  78 317-321
  • 39 Giri A K, Lu L J. Genetic damage and the inhibition of 7,12-dimethylbenz[a]anthracene-induced genetic damage by the phytoestrogens, genistein and daidzein, in female ICR mice.  Cancer Lett. 1995;  95 125-133
  • 40 Krott R, Lebek J, Grisanti S, Esser P, Heimann K. Antiproliferative Wirkung von Genistein auf kultivierte retinale Pigmentepithelzellen vom Schwein.  Ophthalmologica. 2000;  214 296-300
  • 41 Chang H C, Doerge D R. Dietary genistein inactivates rat thyroid peroxidase in vivo without apparent hypothyroid effect.  Toxicol Appl Pharmacol. 2000;  168 244-252
  • 42 Watanabe S, Yamaguchi M, Sobue T, Takahashi T, Miura T, Arai Y, Mazur W, Wahala K, Adlercreutz H. Pharmacokinetics of soybean isoflavones in plasma, urine and feces of men after ingestion of 60 g baked soybean powder (kinako).  J Nutr. 1998;  128 1710-1715
  • 43 Xu X, Wang H J, Murphy P A, Hendrich S. Neither background diet nor type of soy food affects shortterm isofl avone bioavailability in women.  J Nutr. 2000;  130 798-801
  • 44 Bloedon L AT, Jeffcoat A R, Lopaczynski W, Schell M J, Black T M, Dix K J, Thomas B F, Albright C, Busby M G, Crowell J A, Zeisel S H. Safety and pharmacokinetics of purified soy isoflavones: singledose administration to postmenopausal women.  Am J Clin Nutr. 2002;  76 1126-1137
  • 45 Fanti P, Sawaya B P, Custer L J, Franke A A. Serum levels and metabolic clearance of the isoflavones genistein and daidzein in hemodialysis patients.  J Am Soc Nephrol. 1999;  10 864-871
  • 46 Adlercreutz H, Yamada T, Wahala K, Watanabe S. Maternal and neonatal phytoestrogens in Japanese women during birth.  Am J Obstet Gynecol. 1999;  180 737-743
  • 47 Irvine C H, Shand N, Fitzpatrick M G, Alexander S L. Daily intake and urinary excretion of genistein and daidzein by infants fed soy- or dairy-based infant formulas.  Am J Clin Nutr. 1998;  68 (Suppl 6) 1462-1465
  • 48 Setchell K D, Brown N M, Desai P, Zimmer-Nechemias L, Wolfe B E, Brashear W T, Kirschner A S, Cassidy A, Heubi J E. Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements.  J Nutr. 2001;  131 (Suppl 4) 1362-1375
  • 49 Barnes S. Phytoestrogens and breast cancer.  Baillieres Clin Endocrinol Metab. 1998;  12 559-579
  • 50 Stephens F O. Breast cancer: aetiological factors and associations (a possible protective role of phytoestrogens).  Aust N Z J Surg. 1997;  67 755-760
  • 51 Knight D C, Eden J A. A review of the clinical effects of phytoestrogens.  Obstet Gynecol. 1996;  87 897-904
  • 52 Anderson J J, Garner S C. Phytoestrogens and bone.  Baillieres Clin Endocrinol Metab. 1998;  12 543-557
  • 53 Valtuena S, Cashman K, Robins S P, Cassidy A, Kardinaal A, Branca F. Investigating the role of natural phyto-oestrogens on bone health in postmenopausal women.  Br J Nutr. 2003;  89 (Suppl 1) 87-99
  • 54 Eden J. Phytoestrogens and the menopause.  Baillieres Clin Endocrinol Metab. 1998;  12 581-587
  • 55 Glazier M G, Bowman M A. A review of the evidence for the use of phytoestrogens as a replacement for traditional estrogen replacement therapy.  Arch Intern Med. 2001;  161 1161-1172
  • 56 de Kleijn M J, van der Schouw Y T, Wilson P W, Grobbee D E, Jacques P F. Dietary intake of phytoestrogens is associated with a favorable metabolic cardiovascular risk profile in postmenopausal U.S. women: the Framingham study.  J Nutr. 2002;  132 276-282
  • 57 Ramsey L A, Ross B S, Fischer R G. Phytoestrogens and the management of menopause.  Adv Nurse Pract. 1999;  7 26-30
  • 58 Strauss L, Santti R, Saarinen N, Streng T, Joshi S, Makela S. Dietary phytoestrogens and their role in hormonally dependent disease.  Toxicol Lett. 1998;  102-103 349-354
  • 59 Nagata C, Inaba S, Kawakami N, Kakizoe T, Shimizu H. Inverse association of soy product intake with serum androgen and estrogen concentrations in Japanese men.  Nutr Cancer. 2000;  36 14-18
  • 60 Kurzer M S. Hormonal effects of soy in premenopausal women and men.  J Nutr. 2002;  132 570-573
  • 61 Nitzan-Kaluski D, Stern F, Kachel J, Leventhal A. [Soy and phytoestrogens consumption and health policy hesitation or certitude].  Harefuah. 2002;  141 61-66
  • 62 Ibarreta D, Daxenberger A, Meyer H H. Possible health impact of phytoestrogens and xenoestrogens in food.  APMIS. 2001;  109 161-184
  • 63 Kronenberg F, Fugh-Berman A. Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials.  Ann Intern Med. 2002;  137 805-813
  • 64 Cassidy A. Potenzial risks and benefits of phytoestrogen-rich diets.  Int J Vitam Nutr Res. 2003;  73 120-126
  • 65 This P, de la Rochefordiere A, Clough K, Fourquet A, Magdelenat H. Phytoestrogens after breast cancer.  Endocr Relat Cancer. 2001;  8 129-134
  • 66 Lu L J, Tice J A, Bellino F L. Phytoestrogens and healthy aging: gaps in knowledge. A workshop report.  Menopause. 2001;  8 157-170
  • 67 Munro I C, Harwood M, Hlywka J J, Stephen A M, Doull J, Flamm W G, Adlercreutz H. Soy isoflavones: a safety review.  Nutr Rev. 2003;  61 1-33
  • 68 Farrell E. Medical choices available for management of menopause.  Best Pract Res Clin Endocrinol Metab. 2003;  17 1-16
  • 69 Zeisel S H. Regulation of “nutraceuticals”.  Science. 1999;  285 1853-1855
  • 70 Tice J A, Ettinger B, Ensrud K, Wallace R, Blackwell T, Cummings S R. Phytoestrogen supplements for the treatment of hot flashes: the Isoflavone Clover Extract (ICE) Study. A randomized controlled trial.  JAMA. 2003;  290 207-214
  • 71 Muñoz G H, Pluchino S. Cimicifuga racemosa for the treatment of hot flushes in women surviving breast cancer.  Maturitas. 2003;  44 (Suppl 1) 59-65
  • 72 Liske E, Hänggi W, Henneicke von Zepelin H H, Boblitz N, Wüstenberg P, Rahlfs V W, Stat C. Physiological Investigation of a Unique Extract of Black Cohosh (Cimicifuga racemosa rhizoma): A 6-Month Clinical Study Demonstrates No Systemic Estrogenic Effect.  Journal of Womens' Health & Gender-Based Medicine. 2002;  11 163-174
  • 73 Jarry H, Harnischfeger G, Düker E. Studies on the endocrine efficiacy of the constituents of Cimicifuga racemosa: 2. In vitro binding of constituents to estrogen receptors.  Plant Med. 1985;  4 316
  • 74 Huntley A, Ernst E. A systematic review of the safety of black cohosh.  Menopause. 2003;  10 58-64
  • 75 Huntley A L, Ernst E. A systematic review of herbal medicinal products for the treatment of menopausal symptoms.  Menopause. 2003;  10 465-476
  • 76 Cos P, de Bruyne T, Apers S, Berghe D V, Pieters L, Vlietnick A J. Phytoestrogens: Recent Developments.  Planta Med. 2003;  69 589-599
  • 77 Bolego C, Poli A, Cignarella A, Paoletti R. Phytoestrogens: Pharmacological and Therapeutic Perspectives.  Current Drug Targets. 2003;  4 77-87
  • 78 Boué S M, Wiese T E, Nehls S, Burow M E, Elliott S, Carter-Wientjes C H, Shih B Y, McLachlan J A, Cleveland T E. Evaluation of the Estrogenic Effects of Legume Extracts Containing Phytoestrogens.  J Agric Food Chem. 2003;  51 2193-2199
  • 79 Albertazzi P. Purified phytoestrogens in postmenopausal bone health: is there a role for genistein?.  Climacteric. 2002;  5 190-196
  • 80 Zava D T, Duwe G. Estrogenic and antiproliferative properties of genistein and other flavonoids in human breast cancer cells in vitro.  Nutr Cancer. 1997;  27 31-40
  • 81 Brueggemeier R W, Gu X, Mobley J A, Joomprabutra S, Bhat A S, Whetstone J L. Effects of phytoestrogens and synthetic combinatorial libraries on aromatase, estrogen biosynthesis, and metabolism.  Ann N Y Acad Sci. 2001;  948 51-66
  • 82 Maggiolini M, Bonofiglio D, Marsico S, Panno M L, Cenni B, Picard D, Ando S. Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells.  Mol Pharmacol. 2001;  60 595-602
  • 83 Wang W, Liu L Q, Higuchi C M, Chen H. Induction of NADPH: quinone reductase by dietary phytoestrogens in colonic Colo205 cells.  Biochem Pharmacol. 1998;  56 189-195
  • 84 Röhrdanz E, Ohler S, Tran-Thi Q H, Kahl R. The phytoestrogen daidzein affects the antioxidant enzyme system of rat hepatoma H4IIE cells.  J Nutr. 2002;  132 370-375
  • 85 Mesiano S, Katz S L, Lee J Y, Jaffe R B. Phytoestrogens alter adrenocortical function: genistein and daidzein suppress glucocorticoid and stimulate androgen production by cultured adrenal cortical cells.  J Clin Endocrinol Metab. 1999;  84 2443-2448
  • 86 Barnes S, Boersma B, Patel R, Kirk M, Darley-Usmar V M, Kim H, Xu J. Isoflavonoids and chronic disease: mechanisms of action.  Biofactors. 2000;  12 209-215
  • 87 Shir Y, Campbell J N, Raja S N, Seltzer Z. The correlation between dietary soy phytoestrogens and neuropathic pain behavior in rats after partial denervation.  Anesth Analg. 2002;  94 421-426
  • 88 Chen X, Anderson J J. Isoflavones inhibit proliferation of ovarian cancer cells in vitro via an estrogen receptor-dependent pathway.  Nutr Cancer. 2001;  41 165-171
  • 89 de Lemos M L. Effects of soy phytoestrogens genistein and daidzein on breast cancer growth.  Ann Pharmacother. 2001;  35 1118-1121
  • 90 Atanassova N, McKinnell C, Turner K J, Walker M, Fisher J S, Morley M, Millar M R, Groome N P, Sharpe R M. Comparative effects of neonatal exposure of male rats to potent and weak (environmental) estrogens on spermatogenesis at puberty and the relationship to adult testis size and fertility: evidence for stimulatory effects of low estrogen levels.  Endocrinology. 2000;  141 3898-3907
  • 91 Weber K S, Setchell K D, Stocco D M, Lephart E D. Dietary soy-phytoestrogens decrease testosterone levels and prostate weight without altering LH, prostate 5alpha-reductase or testicular steroidogenic acute regulatory peptide levels in adult male Sprague-Dawley rats.  J Endocrinol. 2001;  170 591-599
  • 92 McGarvey C, Cates P A, Brooks A, Swanson I A, Milligan S R, Coen C W, O’Byrne K T. Phytoestrogens and gonadotropin-releasing hormone pulse generator activity and pituitary luteinizing hormone release in the rat.  Endocrinology. 2001;  142 1202-1208
  • 93 Diel P, Smolnikar K, Schulz T, Laudenbach-Leschowski U, Michna H, Vollmer G. Phytoestrogens and carcinogenesis-differential effects of genistein in experimental models of normal and malignant rat endometrium.  Hum Reprod. 2001;  16 997-1006
  • 94 Allred C D, Ju Y H, Allred K F, Chang J, Helferich W G. Dietary genistin stimulates growth of estrogendependent breast cancer tumors similar to that observed with genistein.  Carcinogenesis. 2001;  22 1667-1673
  • 95 Lund T D, Rhees R W, Setchell K D, Lephart E D. Altered sexually dimorphic nucleus of the preoptic area (SDN-POA) volume in adult Long-Evans rats by dietary soy phytoestrogens.  Brain Res. 2001;  914 92-99
  • 96 Lund T D, Lephart E D. Dietary soy phytoestrogens produce anxiolytic effects in the elevated plusmaze.  Brain Res. 2001;  913 180-184
  • 97 Pan Y, Anthony M, Watson S, Clarkson T B. Soy phytoestrogens improve radial arm maze performance in ovariectomized retired breeder rats and do not attenuate benefits of 17beta-estradiol treatment.  Menopause. 2000;  7 230-235
  • 98 Arjmandi B H, Birnbaum R, Goyal N V, Getlinger M J, Juma S, Alekel L, Hasler C M, Drum M L, Hollis B W, Kukreja S C. Bone-sparing effect of soy protein in ovarian hormone-deficient rats is related to its isoflavone content.  Am J Clin Nutr. 1998;  68 (Suppl 6) 1364-1368
  • 99 Kurzer M S, Xu X. Dietary phytoestrogens.  Annu Rev Nutr. 1997;  17 353-381
  • 100 Finking G, Wohlfrom M, Lenz C, Wolkenhauer M, Eberle C, Hanke H. The phytoestrogens Genistein and Daidzein, and 17 beta-estradiol inhibit development of neointima in aortas from male and female rabbits in vitro after injury.  Coron Artery Dis. 1999;  10 607-615
  • 101 Mishra S K, Abbot S E, Choudhury Z, Cheng M, Khatab N, Maycock N J, Zavery A, Aaronson P I. Endothelium-dependent relaxation of rat aorta and main pulmonary artery by the phytoestrogens genistein and daidzein.  Cardiovasc Res. 2000;  46 539-546
  • 102 Clarkson T B, Anthony M S, Morgan T M. Inhibition of postmenopausal atherosclerosis progression: a comparison of the effects of conjugated equine estrogens and soy phytoestrogens.  J Clin Endocrinol Metab. 2001;  86 41-47
  • 103 Foth D, Cline J M. Effects of mammalian and plant estrogens on mammary glands and uteri of macaques.  Am J Clin Nutr. 1998;  68 (Suppl 6) 1413-1417
  • 104 Adlercreutz H, Mousavi Y, Clark J, Hockerstedt K, Hamalainen E, Wahala K, Makela T, Hase T. Dietary phytoestrogens and cancer: in vitro and in vivo studies.  J Steroid Biochem Mol Biol. 1992;  41 331-337
  • 105 Xu X, Duncan A M, Wangen K E, Kurzer M S. Soy consumption alters endogenous estrogen metabolism in postmenopausal women.  Cancer Epidemiol Biomarkers Prev. 2000;  9 781-786
  • 106 Nagata C, Takatsuka N, Shimizu H, Hayashi H, Akamatsu T, Murase K. Effect of soymilk consumption on serum estrogen and androgen concentrations in Japanese men.  Cancer Epidemiol Biomarkers Prev. 2001;  10 179-184
  • 107 Kumar N B, Cantor A, Allen K, Riccardi D, Cox C E. The specific role of isoflavones on estrogen metabolism in premenopausal women.  Cancer. 2002;  94 1166-1174
  • 108 Maskarinec G, Williams A E, Inouye J S, Stanczyk F Z, Franke A A. A randomized isoflavone intervention among premenopausal women.  Cancer Epidemiol Biomarkers Prev. 2002;  11 195-201
  • 109 Dalais F S, Rice G E, Wahlqvist M L, Grehan M, Murkies A L, Medley G, Ayton R, Strauss B J. Effects of dietary phytoestrogens in postmenopausal women.  Climacteric. 1998;  1 124-129
  • 110 Kotsopoulos D, Dalais F S, Liang Y L, McGrath B P, Teede H J. The effects of soy protein containing phytoestrogens on menopausal symptoms in postmenopausal women.  Climacteric. 2000;  3 161-167
  • 111 Quella S K, Loprinzi C L, Barton D L, Knost J A, Sloan J A, LaVasseur B I, Swan D, Krupp K R, Miller K D, Novotny P J. Evaluation of soy phytoestrogens for the treatment of hot flashes in breast cancer survivors: A North Central Cancer Treatment Group Trial.  J Clin Oncol. 2000;  18 1068-1074
  • 112 van Patten C L, Olivotto I A, Chambers G K, Gelmon K A, Hislop T G, Templeton E, Wattie A, Prior J C. Effect of soy phytoestrogens on hot flashes in postmenopausal women with breast cancer: a randomized, controlled clinical trial.  J Clin Oncol. 2002;  20 1449-1455
  • 113 Morabito N, Crisafulli A, Vergara C, Gaudio A, Lasco A, Frisina N, D’Anna R, Corrado F, Pizzoleo M A, Cincotta M, Altavilla D, Lentile R, Squadrito F. Effects of genistein and hormone-replacement therapy on bone loss in early postmenopausal women: a randomized double-blind placebo-controlled study.  J Bone Miner Res. 2002;  10 1904-1912
  • 114 McMichael-Phillips D F, Harding C, Morton M, Roberts S A, Howell A, Potten C S, Bundred N J. Effects of soy-protein supplementation on epithelial proliferation in the histologically normal human breast.  Am J Clin Nutr. 1998;  68 (Suppl 6) 1431-1435
  • 115 Hargreaves D F, Potten C S, Harding C, Shaw L E, Morton M S, Roberts S A, Howell A, Bundred N J. Two-week dietary soy supplementation has an estrogenic effect on normal premenopausal breast.  J Clin Endocrinol Metab. 1999;  84 4017-4024
  • 116 den Tonkelaar I, Keinan-Boker L, Veer P V, Arts C J, Adlercreutz H, Thijssen J H, Peeters P H. Urinary phytoestrogens and postmenopausal breast cancer risk.  Cancer Epidemiol Biomarkers Prev. 2001;  10 223-228
  • 117 Hodgson J M, Puddey I B, Beilin L J, Mori T A, Burke V, Croft K D, Rogers P B. Effects of isoflavonoids on blood pressure in subjects with high-normal ambulatory blood pressure levels: a randomized controlled trial.  Am J Hypertens. 1999;  12 47-53
  • 118 Hodgson J M, Puddey I B, Croft K D, Mori T A, Rivera J, Beilin L J. Isoflavonoids do not inhibit in vivo lipid peroxidation in subjects with high-normal blood pressure.  Atherosclerosis. 1999;  145 167-172
  • 119 Wiseman H, O'Reilly J D, Adlercreutz H, Mallet A I, Bowey E A, Rowland I R, Sanders T A. Isoflavone phytoestrogens consumed in soy decrease F(2)-isoprostane concentrations and increase resistance of low-density lipoprotein to oxidation in humans.  Am J Clin Nutr. 2000;  72 395-400
  • 120 Simons L A, von Konigsmark M, Simons J, Celermajer D S. Phytoestrogens do not influence lipoprotein levels or endothelial function in healthy, postmenopausal women.  Am J Cardiol. 2000;  85 1297-1301
  • 121 Dewell A, Hollenbeck C B, Bruce B. The effects of soy-derived phytoestrogens on serum lipids and lipoproteins in moderately hypercholesterolemic postmenopausal women.  J Clin Endocrinol Metab. 2002;  87 118-121
  • 122 Gerber B, Mylonas I. Senkung des Brustkrebsrisikos.  Zentralbl Gynakol. 2003;  125 6-16

Dr. med. Jörg Melzer

UniversitätsSpital Zürich · Departement für Innere Medizin · Abteilung Naturheilkunde

Rämistr. 100

CH-8091 Zürich

Phone: 00 41-1-2 55-24 60 (Sekretariat, Frau Störl) -24 29 (direkt)

Fax: 00 41-1-2 55-43 94

Email: joerg.melzer@usz.ch