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Semin Thromb Hemost 2004; 30(1): 109-117
DOI: 10.1055/s-2004-822975
Copyright © 2004 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Endothelial Cell Development, Vasculogenesis, Angiogenesis, and Tumor Neovascularization: An Update

Dean G. Tang1 , 2 , Claudio J. Conti2
  • 1Assistant Professor
  • 2Department of Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Science Park Research Division, Smithville, Texas
Further Information

Publication History

Publication Date:
22 March 2004 (online)

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In the embryo, blood vessel formation de novo (vasculogenesis) and from existing vessels (angiogenesis) results in blood vessels lined by endothelial cells (ECs). The relationship between ECs and blood cells suggested by their physical closeness was recently confirmed with the demonstration of progenitors that give rise to both cell types. In tumors, new blood vessel formation has been thought to occur primarily via angiogenesis. Recent evidence, however, suggests that postnatal vasculogenesis also contributes to tumor neovascularization. In this article, we provide an update on EC development, including early lineage specification, morphogenesis or differentiation to form functional blood vessels, and regulation of EC survival and senescence. Furthermore, we review the latest findings on tumor neovascularization and therapeutic potentials of molecules critical to this process.

KEYWORDS

Vasculogenesis - embryo - angiogenesis - angiogenesis - cancer

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 Dr.
Dean Tang

Department of Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Science Park Research Division

Park Road, 1C, Smithville, TX 78957

Email: dtang@sprd1.mdacc.tmc.edu