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Semin Thromb Hemost 2004; 30(1): 127-136
DOI: 10.1055/s-2004-822977
Copyright © 2004 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Mechanisms of Thrombospondin-1-Mediated Metastasis and Angiogenesis

Irene Sargiannidou1 , Cuie Qiu2 , George P. Tuszynski3
  • 1Adjunct instructor, Department of Pathology and Laboratory Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania
  • 2Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania
  • 3Center for Neurovirology and Cancer Biology, Temple University, Philadelphia, Pennsylvania
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Publication History

Publication Date:
22 March 2004 (online)

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The major route of tumor spread is through the bloodstream. Once in circulation, the tumor cells aggregate in clumps with platelets, which enhances the tumor cell survival. The tumor emboli will then adhere to the endothelium and by the release of proteases extravasation of the cells will occur. One of the platelet-secreted proteins is thrombospondin-1. In this article, thrombospondin-1 will be described as a modulator of angiogenesis through its role in regulating endothelial cell apoptosis, protease expression, and vascular endothelial growth factor expression. We hope to convey the idea that activity of thrombospondin-1 in tumor progression is dependent upon its interaction with several host- and tumor-associated proteins.

KEYWORDS

Thrombospondin-1 - metastasis - angiogenesis - proteases - vascular endothelial growth factor

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George P TuszynskiPh.D. 

Center for Neurovirology and Cancer Biology, Temple University

1900 North 12th Street, Philadelphia, PA 19122

Email: gpt@temple.edu