Abstract
Starting from (S )-aspartic, (S )- malic, (S )- citramalic and (S,R )- thiomalic acid, new types of 4,4-difluoro-substituted α-amino-, α-hydroxy- and α-mercaptopentanoic acids have been synthesized, applying hexafluoroacetone as protecting and activating reagent. The new partially fluorinated α-functionalized carboxylic acids represent interesting monomers for peptide and depsipeptide modification and for rational design and elucidation of secondary structure.
Key words
amino acids - hydroxy acids - mercapto acids - fluorine - peptides
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