Synthesis, Table of Contents SHORTPAPER © Georg Thieme Verlag Stuttgart · New York A Direct Preparation of 6-Methylene-2-cyclohexenones George A. Kraus*, Junwon KimDepartment of Chemistry, Iowa State University, Ames, IA 50011, USAe-Mail: gakraus@iastate.edu; Recommend Article Abstract Buy Article All articles of this category Abstract The reaction of enol silyl ethers with Eschenmoser’s salt, followed by methylation and elimination, provides ready access to 6-methylene-2-cyclohexenones. Key words Eschenmoser’s salt - 6-methylene-2-cyclohexenones - enol silyl ethers Full Text References References 1 Kraus GA. Kim J. Tetrahedron Lett. 2004, 45: 1457 2 Wiberg KB. Jason ME. J. Am. Chem. Soc. 1976, 98: 3393 3 Reddy PV. Prakash AM. Chakrabarty DK. Bhat SV. J. Chem. Res., Synop. 1997, 306 4 Gras JL. Tetrahedron Lett. 1978, 24: 2111 5 Ksander GM. McMurry JE. Johnson M. J. Org. Chem. 1977, 42: 1180 6 Danishefsky S. Kitahara T. McKee R. Schuda PF. J. Am. Chem. Soc. 1976, 98: 6715 7 Warnhoff EW. Johnson WS. J. Am. Chem. Soc. 1953, 75: 494 8a The enol silyl ether of cyclohexenone is commercially available. The other enol silyl ethers were prepared by the procedure of Simchen: Emde H. Goetz A. Hofmann K. Simchen G. Liebigs Ann. Chem. 1981, 1643 8b Rubottom GM. Gruber JM. J. Org. Chem. 1977, 42: 1051
