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Synthesis 2004(13): 2186-2190
DOI: 10.1055/s-2004-829178
DOI: 10.1055/s-2004-829178
PAPER
© Georg Thieme Verlag Stuttgart · New York
An Improved Catalytic System, Pd(PPh3)4/PhCOOH Combined Catalyst, for the Allylation of Carbon Pronucleophiles with Allenes
Further Information
Received
21 April 2004
Publication Date:
27 July 2004 (online)
Publication History
Publication Date:
27 July 2004 (online)
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Abstract
The reaction of allenes with active methynes and methylenes proceeded smoothly in the presence of Pd(PPh3)4/PhCOOH combined catalyst to give the corresponding monoallylated products with E-stereoselectivity in good to high yields. This result is in marked contrast to the previous finding that the reaction of allenes with active methynes, in the presence of Pd2(dba)3·CHCl3/dppb catalyst, affords the allylation products in lower yield with lower stereoselectivities.
Key words
palladium - carboxylic acids - catalysis - allenes - C-nucleophiles
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