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Exp Clin Endocrinol Diabetes 2005; 113(1): 35-37
DOI: 10.1055/s-2004-830524
Article

J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Levels of Plasma Fibrinogen and D-Dimer in Patients with Impaired Fasting Glucose

E. Coban1 , R. Sari2 , M. Ozdogan1 , F. Akcit3
  • 1Department of Internal Medicine, Akdeniz University Faculty of Medicine, Antalya, Turkey
  • 2Division of Endocrinology, Akdeniz University Faculty of Medicine, Antalya, Turkey
  • 3Department of Biochemistry, Akdeniz University Faculty of Medicine, Antalya, Turkey
Further Information

Publication History

Received: January 19, 2004 First decision: May 25, 2004

Accepted: June 28, 2004

Publication Date:
21 January 2005 (online)

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Abstract

Background: Cardiovascular risk associated with impaired fasting glucose has been examined in various studies with conflicting results. During the last 10 years, several risk markers for atherosclerosis such as fibrinogen and D-dimer have been identified. The present study was designed to evaluate plasma fibrinogen and D-dimer levels in patients with impaired fasting glucose compared with normal subjects and those with type 2 diabetes mellitus.

Methods: Age-, sex-, and body mass index-matched 30 normal subjects, 30 patients with impaired fasting glucose (fasting glucose 110 to 125 mg/dl), and 30 patients with type 2 diabetes mellitus (fasting glucose ≥ 126 mg/dl) were included in the study.

Results: The levels of plasma fibrinogen in patients with type 2 diabetes mellitus, impaired fasting glucose, and normal subjects were 449 (306 - 605) mg/dl, 348 (264 - 468) mg/dl, and 216 (179 - 260) mg/dl, respectively. Patients with impaired fasting glucose had significantly lower plasma fibrinogen levels than patients with type 2 diabetes mellitus (p < 0.05). There were significantly higher plasma fibrinogen levels in patients with impaired fasting glucose than in normal subjects (p < 0.05). The levels of plasma D-dimer in patients with type 2 diabetes mellitus, impaired fasting glucose, and normal subjects were 615 (505 - 768) mg/l, 518 (412 - 664) mg/l, and 424 (356 - 557) mg/l, respectively. Patients with impaired fasting glucose had significantly lower plasma D-dimer levels than patients with type 2 diabetes mellitus (p < 0.05). There were significantly higher plasma D-dimer levels in patients with impaired fasting glucose than in normal subjects (p < 0.05). The levels of plasma fibrinogen and D-dimer were related to fasting glucose in type 2 diabetes mellitus and impaired fasting glucose groups (p < 0.05). We also detected positive correlation between plasma fibrinogen levels and age in study groups (p < 0.05).

Conclusion: Our data suggest that patients with impaired fasting glucose pose a hypofibrinolytic status and cardiovascular risk, although this was lower than in patients with type 2 diabetes mellitus.

Key words

Impaired fasting glucose - fibrinogen - D-dimer - cardiovascular risk

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MD Erkan Coban

Akdeniz University Faculty of Medicine
Department of Internal Medicine

07070 Antalya

Turkey

Phone: + 902422274343 ext 55139

Fax: + 90 24 22 27 44 90

Email: ecoban@akdeniz.edu.tr