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Synthesis 2004(14): 2277-2282
DOI: 10.1055/s-2004-831177
DOI: 10.1055/s-2004-831177
PAPER
© Georg Thieme Verlag Stuttgart · New York
3-Acylindoles via a One-Pot, Regioselective Friedel-Crafts Reaction
Further Information
Received
5 April 2004
Publication Date:
17 August 2004 (online)
Publication History
Publication Date:
17 August 2004 (online)
Abstract
Within we report a general one-pot high-yielding Friedel-Crafts acylation of indole using acid chlorides and diethylaluminum chloride in gram scale quantities. This general synthesis affords products that are easily isolated and require no complex purification procedures.
Key words
indole - regioselectivity - Friedel-Crafts reactions - acylations
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References
Wynne, J. H.; Jones-Meehan, J. US Naval Research Laboratory, Washington, D. C., 2004, unpublished work.