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Synthesis 2005(3): 496-499  
DOI: 10.1055/s-2004-831196
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© Georg Thieme Verlag Stuttgart · New York

Preparation of N-Aryl Compounds by Amino Acid-Promoted Ullmann-Type Coupling Reactions

Qian Caia, Wei Zhub, Hui Zhangb, Yongda Zhangb, Dawei Ma*a
a State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, 354 Fenglin Lu, Shanghai 200032, P. R. of China
Fax: +86(21)64166128; e-Mail: madw@mail.sioc.ac.cn;
b Department of Chemistry, Fudan University, Shanghai 200433, P. R. of China
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Publication History

Received 1 June 2004
Publication Date:
21 October 2004 (online)

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Abstract

N-Aryl α- or β-amino acids, aryl amines, N-arylpyrroles, N-arylindoles, N-arylimidazoles, N-arylpyrazoles and aryl azides are prepared by CuI-catalyzed coupling reactions of aryl halides with corresponding nitrogen sources using amino acids as the promoters.

Key words

aryl amines - coupling reaction - amino acids - aryl halides