Novel Synthesis of Optically Pure Indolylglycinols Using Lipase-Mediated Resolution

Takashi Kouko; Jun-ichi Kobayashi; Asami Ohta; Masanori Sakamoto; Tomomi Kawasaki

doi:10.1055/s-2004-831217

PAPER

Novel Synthesis of Optically Pure Indolylglycinols Using Lipase-Mediated Resolution

Takashi Kouko, Jun-ichi Kobayashi, Asami Ohta, Masanori Sakamoto, Tomomi Kawasaki*
Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan
Fax: +81(424)958763; e-Mail: kawasaki@my-pharm.ac.jp;

Abstract

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Abstract

Optically pure indolylglycinols were prepared from indolin-3-ones through lipase-mediated kinetic resolution of 2-azido-2-(indol-3-yl)ethyl acetates.

Key words

kinetic resolution - enzymes - amino alcohols - indoles - hydrolysis

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References

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