Abstract
Bisubstituted or 1,2,2-trisubstituted vinyl phosphine oxides were prepared stereoselectively by the carbocupration of acetylenic phosphine oxides followed by hydrolysis or by reacting with other electrophiles.
Keywords
carbocupration - acetylenic phosphine oxide - polysubstituted vinyl phosphine oxides
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Crystal Data for 4g: C25 H25 OP, MW = 372.45, monoclinic, space group, P21 /n, a = 19.002(4), b = 6.305(2), c = 18.514(6) Å, β = 110.66(2)o , V = 2075(1) Å3 , T = 293K, Z = 4, Dc = 1.92 g·cm-1 , µ = 1.44 mm-1 , λ = 0.71069 Å, F(000) = 792.00, independent reflections (R
int = 0.000), 8478 reflections collected; refinement method, full-matrix least-squares refinement on F2 ; goodness-of-fit on F
²
= 0.223; Final R indices [ I > 2 σ (I)] R 1 = 0.050, wR 2 = 0.094.