Zelluläre Immuntherapie beim fortgeschrittenen Mammakarzinom mittels tumorantigenspezifischer reaktivierter, autologer T-Memory Zellen des Knochenmarks im Sinne einer Phase-I-Studie

Literatur

• 1 Solomayer E F, Feuerer M, Bai L, Umansky V, Beckhove P, Meyberg G C, Bastert G, Schirrmacher V, Diel I J. Influence of adjuvant hormone therapy and chemotherapy on the immune system analysed in the bone marrow of patients with breast cancer.  Clin Cancer Res. 2003;  9 174
• 2 Schuetz F, Ehlert K, Beckhove P, Diel I J, Solomayer E, Schirrmacher V, Bastert G, Strittmatter H J. Cellular immunotherapy in late stage breast cancer patients with reactivated autologous Memory T-cells (MTC) derived from bone marrow (BM).  Breast. 2003;  77
• 3 Feuerer M, Beckhove P, Bai L, Solomayer E F, Bastert G, Diel I J, Pedain C, Oberniedermayer M, Schirrmacher V, Umansky V. Therapy of human tumors in NOD/Scid mice with patients-derived reactivated memory T cells from bone marrow.  Nature Med. 2001;  7
• 4 Beckhove P, Schuetz F, Diel I J, Solomayer E F, Bastert G, Foerster J, Feuerer M, Bai L, Sinn H P, Umansky V, Schirrmacher V. Efficient engraftment of human primary breast cancer transplants in nonconditioned NOD/Scid mice.  J Clin Invest. 2004;  105 444-453
• 5 Bennett R, Jarvela T, Engelhardt P, Kostamovaara L, Sparks P, Carpen O, Turunen O, Vaheri A. Mucin MUC1 is seen in cell surface protrusions together with ezrin in immunoelectron tomography and is concentrated at tips of filopodial protrusions in MCF-7 breast carcinoma cells.  J Histochem Cytochem. 2001;  49 67-77
• 6 Dolo V, Adobati E, Canevari S, Picone M A, Vittorelli M L. Membrane vesicles shed into the extracellular medium by human breast carcinoma cells carry tumor-associated surface antigens.  Clin Exp Metastasis. 1995;  13 277-286
• 7 Rose H N, McGrath C M. Alpha-lactalbumin production in human mammary carcinoma.  Science. 1975;  190 673-675