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DOI: 10.1055/s-2004-834726
Diagnose und Differenzialdiagnose der leichten kognitiven Beeinträchtigung
Diagnosis and Differential Diagnosis of Mild Cognitive ImpairmentPublication History
Publication Date:
29 August 2005 (online)
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Weiterbildungsziele In diesem Beitrag sollen folgende Weiterbildungsziele vermittelt werden: Kenntnis des Störungsbildes Diagnose und Diagnosekriterien Differenzialdiagnose Stellenwert von Neuropsychologie und Bildgebung Prognose Problematik des nosologischen Konzeptes
Literatur
- 1 Dubois B, Albert M L. Amnestic MCI or prodromal Alzheimer's disease?. Lancet Neurol. 2004; 3 246-248
- 2 Grady C L, Haxby J V, Horwitz B. et al . Longitudinal study of the early neuropsychological and cerebral metabolic changes in dementia of the Alzheimer type. J Clin Exp Neuropsychol. 1988; 10 576-596
- 3 Flicker C, Ferris S H, Reisberg B. Mild cognitive impairment in the elderly: predictors of dementia. Neurology. 1991; 41 1006-1009
- 4 Petersen R C, Doody R, Kurz A. et al . Current concepts in mild cognitive impairment. Arch Neurol. 2001; 58 1985-1992
- 5 Collie A, Maruff P. An analysis of systems of classifying mild cognitive impairment in older people. Australian and New Zealand Journal of Psychiatry. 2002; 36 133-140
- 6 Busse A, Bischkopf J, Riedel-Heller S G. et al . Mild cognitive impairment: prevalence and incidence according to different diagnostic criteria. Results of the Leipzig Longitudinal Study of the Aged (LEILA75+). Br J Psychiatry. 2003; 182 449-454
- 7 Kral V A. Senescent forgetfulness: benign and malignant. Can Med Assoc J. 1962; 86 257-260
- 8 Crook T, Bartus R, Ferris S H. et al . Age-assoziated memory impairment: Proposed diagnostic criteria and measures of clinical change: report of a National Institute of Mental Health Work Group. Dev Neuropsychol. 1986; 2 261-276
- 9 O'Brien J T, Levy R. Age associated memory impairment. BMJ. 1992; 304 5-6
- 10 Rosen T J. „Age-associated memory impairment”: a critique. European J Cognitive Psychol. 1990; 2 275-287
- 11 Saß H, Wittchen H-U, Zaudig M. Diagnostisches und Statistisches Manual Psychischer Störungen. Göttingen; Hogrefe-Verlag 1994
- 12 Dilling H, Mombour W, Schmid M H. et al .Weltgesundheitsorganisation: Internationale Klassifikation psychischer Störungen. ICD-10. Bern, Göttingen, Toronto, Seattle; Huber 1994
- 13 Petersen R C, Smith G E, Waring S C. et al . Mild cognitive impairment: clinical characterization and outcome. Arch Neurol. 1999; 56 303-308
- 14 Morris J C, Storandt M, Miller J P. et al . Mild cognitive impairment represents early-stage Alzheimer disease. Arch Neurol. 2001; 58 397-405
- 15 Tierney M C, Szalai J P, Snow W G. et al . Prediction of probable Alzheimer's disease in memory-impaired patients: a prospective longitudinal study. Neurology. 1996; 46 661-665
- 16 Shah Y, Tangalos E G, Petersen R C. Mild cognitive impairment. When is it a precursor to Alzheimer's disease? Geriatrics. 2000; 55 62-68
- 17 Busse A, Bischkopf J, Riedel-Heller S G. et al . Subclassifications for mild cognitive impairment: prevalence and predictive validity. Psychol Med. 2003; 33 1029-1038
- 18 Jorm A F, Christensen H, Korten A E. et al . Memory complaints as a precursor of memory impairment in older people: a longitudinal analysis over 7 - 8 years. Psychol Med. 2001; 31 441-449
- 19 Jonker C, Geerlings M I, Schmand B. Are memory complaints predictive for dementia? A review of clinical and population-based studies. Int J Geriatr Psychiatry. 2000; 15 983-991
- 20 Smith G E, Petersen R C, Ivnik R J. et al . Subjective memory complaints, psychological distress, and longitudinal change in objective memory performance. Psychol Aging. 1996; 11 272-279
- 21 Jorm A F, Scott R, Jacomb P A. Assesment of cognitive decline in dementia by informant questionnaire. Int J Geriatr Psychiatry. 1989; 4 35-39
- 22 Folstein M F, Folstein S E, McHugh P R. „Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12 189-198
- 23 Ganguli M, Belle S, Ratcliff G. et al . Sensitivity and specificity for dementia of population-based criteria for cognitive impairment: the MoVIES project. J Gerontol. 1993; 48 M152-M161
- 24 Kukull W A, Larson E B, Teri L. et al . The Mini-Mental State Examination score and the clinical diagnosis of dementia. J Clin Epidemiol. 1994; 47 1061-1067
- 25 Albert M S, Moss M B, Tanzi R. et al . Preclinical prediction of AD using neuropsychological tests. J Int Neuropsychol Soc. 2001; 7 631-639
- 26 Jacobson N S, Truax P. Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. J Consult Clin Psychol. 1991; 59 12-19
- 27 Wolf H, Jelic V, Gertz H J. et al . A critical discussion of the role of neuroimaging in mild cognitive impairment. Acta Neurol Scand Suppl. 2003; 179 52-76
- 28 Leon M J de, Convit A, George A E. et al . In vivo structural studies of the hippocampus in normal aging an in incipient Alzheimer's disease. Ann-N-Y-Acad-Science. 1996; 777 1-13
- 29 Laakso M P, Soininen H, Partanen K. et al . MRI of the hippocampus in Alzheimer's disease: sensitivity, specificity, and analysis of the incorrectly classified subjects. Neurobiology-of-aging. 1998; 19 23-31
- 30 Jack Jr C R, Petersen R C, Xu Y C. et al . Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment. Neurology. 1999; 52 1397-1403
- 31 Korf E S, Wahlund L O, Visser P J. et al . Medial temporal lobe atrophy on MRI predicts dementia in patients with mild cognitive impairment. Neurology. 2004; 63 94-100
- 32 Jack Jr C R, Petersen R C, Xu Y. et al . Rates of hippocampal atrophy correlate with change in clinical status in aging and AD. Neurology. 2000; 55 484-489
- 33 Burns A, Zaudig M. Mild cognitive impairment in older people. Lancet. 2002; 360 1963-1965
- 34 Drzezga A, Lautenschlager N, Siebner H. et al . Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer's disease: a PET follow-up study. Eur J Nucl Med Mol Imaging. 2003; 30 1104-1113
- 35 Chetelat G, Desgranges B, Sayette V De la. et al . Mild cognitive impairment: Can FDG-PET predict who is to rapidly convert to Alzheimer's disease. Neurology. 2003; 60 1374-1377
- 36 Hampel H, Goernitz A, Buerger K. Advances in the development of biomarkers for Alzheimer's disease: from CSF total tau and Abeta(1 - 42) proteins to phosphorylated tau protein. Brain Res Bull. 2003; 61 243-253
- 37 Schoonenboom N S, Pijnenburg Y A, Mulder C. et al . Amyloid beta(1 - 42) and phosphorylated tau in CSF as markers for early-onset Alzheimer disease. Neurology. 2004; 62 1580-1584
- 38 Maruyama M, Matsui T, Tanji H. et al . Cerebrospinal fluid tau protein and periventricular white matter lesions in patients with mild cognitive impairment: implications for 2 major pathways. Arch Neurol. 2004; 61 716-720
- 39 Buerger K, Teipel S J, Zinkowski R. et al . CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects. Neurology. 2002; 59 627-629
- 40 Zetterberg H, Wahlund L O, Blennow K. Cerebrospinal fluid markers for prediction of Alzheimer's disease. Neurosci Lett. 2003; 352 67-69
- 41 Arai H, Ishiguro K, Ohno H. et al . CSF phosphorylated tau protein and mild cognitive impairment: a prospective study. Exp Neurol. 2000; 166 201-203
- 42 Andreasen N, Vanmechelen E, Vanderstichele H. et al . Cerebrospinal fluid levels of total-tau, phospho-tau and A beta 42 predicts development of Alzheimer's disease in patients with mild cognitive impairment. Acta Neurol Scand Suppl. 2003; 179 47-51
- 43 Andreasen N, Minthon L, Vanmechelen E. et al . Cerebrospinal fluid tau and Abeta42 as predictors of development of Alzheimer's disease in patients with mild cognitive impairment. Neurosci Lett. 1999; 273 5-8
- 44 Blennow K. CSF biomarkers for mild cognitive impairment. J Intern Med. 2004; 256 224-234
- 45 Christensen H, Griffiths K, Mackinnon A. et al . A quantitative review of cognitive deficits in depression and Alzheimer-type dementia. J Int Neuropsychol Soc. 1997; 3 631-651
- 46 Robbins T W, Elliott R, Sahakian B J. Neuropsychology - dementia and affective disorders. Br Med Bull. 1996; 52 627-643
- 47 Visser P J, Verhey F R, Ponds R W. et al . Distinction between preclinical Alzheimer's disease and depression. J Am Geriatr Soc. 2000; 48 479-484
- 48 Rubin E H, Kinscherf D A. Psychopathology of very mild dementia of the Alzheimer type. Am J Psychiatry. 1989; 146 1017-1021
- 49 Robbins T W, Elliott R, Sahakian B J. Neuropsychology - dementia and affective disorders. Br Med Bull. 1996; 52 627-643
- 50 Geerlings M I, Schoevers R A, Beekman A T. et al . Depression and risk of cognitive decline and Alzheimer's disease. Results of two prospective community-based studies in The Netherlands. Br J Psychiatry. 2000; 176 568-575
- 51 Nygard L. Instrumental activities of daily living: a stepping-stone towards Alzheimer's disease diagnosis in subjects with mild cognitive impairment?. Acta Neurol Scand Suppl. 2003; 179 42-46
- 52 Hughes C P, Berg L, Danziger W L. et al . A new clinical scale for the staging of dementia. Br J Psychiatry. 1982; 140 566-572
- 53 Reisberg B, Ferris S H, Leon M J de. et al . The global deterioration scale (GDS): an instrument for the assessment of primary degenerative dementia (PDD). Am J Psychiatry. 1982; 139 1135-1139
- 54 Davis H S, Rockwood K. Conceptualization of mild cognitive impairment: a review. Int J Geriatr Psychiatry. 2004; 19 313-319
- 55 Ingles J L, Wentzel C, Fisk J D. et al . Neuropsychological predictors of incident dementia in patients with vascular cognitive impairment, without dementia. Stroke. 2002; 33 1999-2002
- 56 Wentzel C, Rockwood K, MacKnight C. et al . Progression of impairment in patients with vascular cognitive impairment without dementia. Neurology. 2001; 57 714-716
- 57 Luca C R De, Wood S J, Anderson V. et al . Normative data from the CANTAB. I: development of executive function over the lifespan. J Clin Exp Neuropsychol. 2003; 25 242-254
- 58 Mast R C van der, Broek W W van den, Fekkes D. et al . Incidence of and preoperative predictors for delirium after cardiac surgery. J Psychosom Res. 1999; 46 479-483
- 59 Rockwood K. The occurence and duration of symptoms in elderly patients with delirium. J Gerontol. 1993; 48 162-166
- 60 Francis J, Kapoor W N. Prognosis after hospital discharge of older medical patients with delirium. J Am Geriatr Soc. 1992; 40 601-606
- 61 Newman M F, Kirchner J L, Phillips-Bute B. et al . Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery. N Engl J Med. 2001; 344 395-402
- 62 McKhann G M, Borowicz L M, Goldsborough M A. et al . Depression and cognitive decline after coronary artery bypass grafting. Lancet. 1997; 349 1282-1284
- 63 Raja P V, Blumenthal J A, Doraiswamy P M. Cognitive deficits following coronary artery bypass grafting: prevalence, prognosis, and therapeutic strategies. CNS Spectr. 2004; 9 763-772
- 64 Selnes O A, Royall R M, Grega M A. et al . Cognitive changes 5 years after coronary artery bypass grafting: is there evidence of late decline?. Arch Neurol. 2001; 58 598-604
- 65 Ho P M, Arciniegas D B, Grigsby J. et al . Predictors of cognitive decline following coronary artery bypass graft surgery. Ann Thorac Surg. 2004; 77 597-603
- 66 Selnes O A, Grega M A, Borowicz Jr L M. et al . Cognitive changes with coronary artery disease: a prospective study of coronary artery bypass graft patients and nonsurgical controls. Ann Thorac Surg. 2003; 75 1377-1384
- 67 Kurz A, Diehl J, Riemenschneider M. et al . Leichte kognitive Störung, Fragen zu Definition, Diagnose, Prognose und Therapie. Nervenarzt. 2004; 75 6-15
- 68 Allain H, Bentue-Ferrer D, Akwa Y. Mild cognitive impairment: a treatment at last?. Lancet Neurol. 2004; 3 643
- 69 Voisin T, Touchon J, Vellas B. Mild cognitive impairment: a nosological entity?. Curr Opin Neurol. 2003; 16, Suppl 2 S43-S45
- 70 Zimmermann P, Fimm B. Testbatterie zur Aufmerksamkeitsprüfung (TAP) Version 1.7. Herzogenrath; Psytest 2002
- 71 Thalmann B, Monsch A U, Bernasconi F. et al .Die CERAD Neuropsychologische Testbatterie. Ein gemeinsames minimales Instrumentarium zur Demenzabklärung. Basel; Memory Clinic 1998
- 72 Härting C, Markowitsch H J, Neufeld H. et al .Wechsler Gedächtnistest - Revidierte Fassung. Dt. Adaptation der revidierten Fassung der Wechsler Memory Scale. Bern; Hans Huber 2000
- 73 Helmstaedter C, Lendt M, Lux S. Verbaler Lern- und Merkfähigkeitstest. Göttingen; Beltz Test 2001
- 74 Gagnon M, Awad N, Mertens V B. et al . Comparing the Rey and Taylor complex figures: a test-retest study in young and older adults. J Clin Exp Neuropsychol. 2003; 25 878-890
- 75 Tewes U. Hamburg-Wechsler Intelligenztest für Erwachsene - Revision (2. korr. Aufl.). Göttingen; Hogrefe 1991
- 76 Aschenbrenner S, Tucha O, Lange K W. RWT - Regensburger Wortflüssigkeits-Test. Göttingen; Hogrefe 2000
- 77 Osswald W D, Fleischmann U M. Das Nürnberger Altersinventar (NAI) (4. Aufl.). Göttingen; Hogrefe 1997
- 78 Glindemann R, Klintwort D, Ziegler W. et al .Bogenhausener Semantik-Untersuchung BOSU. München; Urban & Fischer 2002
Dipl.-Psych. B. Heimann
Sektion Neuropsychologie der Klinik für Neurologie · Universitätsklinik Magdeburg
Leipziger Straße 44
39120 Magdeburg
Email: birgit.heimann@medizin.uni-magdeburg.de