Synthesis of New Polycyclic β-Lactams via One-Pot Enyne Metathesis and Diels-Alder Reactions

Nicolas Desroy; Fabien Robert-Peillard; Julie Toueg; Charlotte Hénaut; Romain Duboc; Marie-Noëlle Rager; Monique Savignac; Jean-Pierre Genêt

doi:10.1055/s-2004-834877

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Synthesis of New Polycyclic β-Lactams via One-Pot Enyne Metathesis and Diels-Alder Reactions

Nicolas Desroy^a, Fabien Robert-Peillard^a, Julie Toueg^a, Charlotte Hénaut^a, Romain Duboc^a, Marie-Noëlle Rager^b, Monique Savignac*^a, Jean-Pierre Genêt*^a
^a Ecole Nationale Supérieure de Chimie de Paris, Laboratoire de Synthèse Sélective Organique et Produits Naturels, UMR 7573, 11 rue Pierre et Marie Curie, 75231 Paris cedex 05, France
Fax: +33(144)071062; e-Mail: genet@ext.jussieu.fr; savignac@ext.jussieu.fr;
^b Service de RMN de l’ENSCP, Ecole Nationale Supérieure de Chimie de Paris, 11 rue Pierre et Marie Curie, 75231 Paris cedex 05, France

Abstract

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Abstract

One-pot ring-closing enyne metathesis and Diels-Alder reactions led to efficient synthesis of tricyclic and tetracyclic β-lactams.

Key words

metathesis - Diels-Alder cycloaddition - one-pot reactions - polycycles - lactams

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References

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