Synthesis, Table of Contents PAPER © Georg Thieme Verlag Stuttgart · New York ω-Functionalized 3-Alkynylpyrazolo[1, 5-a]pyrimidines by Sonogashira Coupling Lunxiang Yin, Jürgen Liebscher* Institut für Chemie, Humboldt-Universität Berlin, Brook-Taylor-Straße 2, 12489 Berlin, GermanyFax: +49(30)20937552; e-Mail: liebscher@chemie.hu-berlin.de; Recommend Article Abstract Buy Article All articles of this category Abstract ω-Functionalized 3-alkynylpyrazolo[1,5-a]pyrimidines were synthesized via the Pd-C/CuI/PPh3-catalyzed Sonogashira coupling of 3-iodopyrazolo[1,5-a]pyrimidines with propargylic and homopropargylic compounds. Subsequent Pd-C-catalyzed hydrogenation of the C-C triple bond afforded 3-(3-dimethylaminopropyl)-pyrazolo[1,5-a]pyrimidines. Keywords heterocycles - alkynes - cross-coupling - palladium - hydrogenation Full Text References References 1 Novinson T. Bhooshan B. Okabe T. Revankar GR. Wilson HR. J. Med. Chem. 1976, 19: 512 2 Senga K. Novinson T. Wilson HR. J. Med. 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