Cardiomyopathy is a major cause of death in overt acromegaly. Recent progress in research has increasingly revealed the molecular mechanisms concerning growth hormone and insulin-like growth factor in the development of heart failure. In this article, we propose mechanisms according to which heart failure occurs, and we aim to extrapolate this knowledge to more general processes involved in heart failure.
KEYWORDS
Acromegaly - cardiovascular disease - insulin-like growth factor - cardiac adaptive properties
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Marcel Th.B TwicklerM.D. Ph.D. (UU) Ph.D. (Paris VI)
Department of Endocrinology and Metabolic Diseases
UMC St. Radboud, Catholic University Nijmegen/Radboud University
Geert Grooteplein-Zuid 8, 6525 GA Nijmegen, The Netherlands
