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DOI: 10.1055/s-2005-837383
© Georg Thieme Verlag Stuttgart · New York
Neuroimmunologische Aspekte funktioneller somatischer Syndrome
Neuroimmune interactions in functional-somatic syndromesPublication History
eingereicht: 20.4.2004
akzeptiert: 14.10.2004
Publication Date:
14 January 2005 (online)
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Glossar
ACTH = Adrenokortikotropes Hormon
ANS = Autonomes Nervensystem
aMSH = ALPHA-Melanozyten stimulierendes Hormon
AVP = Arginin-Vasopressin
CRH = Corticotropin releasing Hormon
FSH = Follikelstimulierendes Hormon
HPA = Hypothalamus-Hypophysen-Nebennieren-Achse
HPG = Hypothalamus-Hypophysen-Gonaden-Achse
HPS = Hypothalamus-Hypophysen-Wachstums-Achse
HPT = Hypothalamus-Hypophysen-Schilddrüsen-Achse
LC = Locus coeruleus
LH = Luteiniserendes Hormon
LHRH = Luteinisierendes Hormon Releasing Hormon
NE = noradrenerge Neurone
NFG = Nerve growth Factor
NPY = Neuropeptid Y
PVN = paraventrikulärer Nukleus
VIP = vasoaktives intestinales Peptid
Literatur
- 1 Aaron L A, Buchwald D. A review of the evidence for overlap among unexplained clinical conditions. Ann Intern Med. 2001; 134 868-881
- 2 Ader R. Conditioned immunomodulation: Research needs and directions. Brain Behavior and Immunity. 2003; 17 S51-S57
- 3 Anisman H, Merali Z. Cytokines, stress and depressive illness: brain-immune interactions. Ann Med. 2003; 35 2-11
- 4 Arlt W, Callies F, van Vlijmen J C. et al . Dehydroepiandrosterone replacement in women with adrenal insufficiency. New Engl J Med. 1999; 341 1013-20
- 5 Barsky A J, Borus J F. Functional somatic syndromes. Ann Intern Med. 1999; 130 910-921
- 6 Bedoui S, Kawamura N, Straub R H, Pabst R, Yamamura T, von Hörsten S. Relevance of neuropeptide Y for the neuroimmune crosstalk. J Neuroimmunol. 2003; 134 1-11
- 7 Bennett R M. Adult growth hormone deficiency in patients with fibromyalgia. Curr Rheumatol Reports. 2002; 4 306-312
- 8 Benoist C, Mathis D. Mast cells in autoimmune disease. Nature. 2002; 420 875-878
- 9 Berg P A. Chronisches Müdigkeits- und Fibromyalgiesyndrom. 2nd ed Berlin, Heidelberg, New York: Springer In: Berg PA, editor. Chronisches Müdigkeits- und Fibromyalgiesyndrom. Manifestation einer generalisierten neuroregulativen Funktionsstörung 2003: 3-24
- 10 Berg P A, Klein R. Fibromyalgie-Syndrom. Eine neuroendokrinologische Erkrankung. Dtsch Med Wochenschr. 1994; 119 424-435
- 11 Borda T, Perez Rivera R, Joensen L, Gomez R M, Sterin-Borda L. Antibodies against cerebral M1 cholinergic muscarinic receptor from schizophrenic patients: molecular interaction. J Immunol. 2002; 168 3667-3674
- 12 Boudarene M, Legros J J, Timsit-Berthier M. Study of the stress response: role of anxiety, cortisol and DHEAs. Encephale. 2002; 28 139-146
- 13 Capuron L, Dantzer R. Cytokines and depression: The need for a new paradigm. Brain, Behavior and Immunity. 2003; 17 S119-S124
- 14 Caspi A, Sugden K, Moffitt T E. et al . Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003; 301 386-389
- 15 Chrousos G P, Gold P W. The concepts of stress and stress system disorders. JAMA. 1992; 267 1244-1252
- 16 Cleare A J. The neuroendocrinology of chronic fatigue syndrome. Endocrine Rev. 2003; 24 236-252
- 17 Crofford L J, Clauw D J. Fibromyalgia: Where are we a decade after the american college of rheumatology classification criteria were developed?. Arthritis Rheum. 2002; 46 1136-1138
- 18 Csef H. Funktionelle (somatoforme) Störungen beim internistischen Hausbesuch. Internist. 2001; 42 1476-1487
- 19 Demitrack M A, Crofford L J. Evidence for and pathophysiologic implications of hypothalamic-pituitary-adrenal axis dysregulation in fibromyalgia and chronic fatigue syndrome. Ann N Y Acad Sci. 1998; 840 684-697
- 20 Egle U T, Egle-Ecker M -L, Nickel R, van Hodenhove B. Fibromyalgie als Störung der zentralen Schmerz- und Stressverarbeitung. Psychother Psych Med. 2003; 53 1-11
- 21 Elenkov I J, Chrousos G P, Wilder R L. Neuroendocrine regulation of IL-12 and TNF-alpha/IL-10 balance. Clinical implications. Ann N Y Acad Sci. 2000; 917 94-105
- 22 Eskandari F, Sternberg E M. Neural-immune interactions in health and disease. Ann N Y Acad Sci. 2002; 966 20-27
- 23 Fetissov S O, Hallman J, Oreland L. et al . Autoantibodies against (-MSH, ACTH, and LHRH in anorexia and bulimia nervosa patients. Proc Natl Acad Sci USA. 2002; 99 17155-17160
- 24 Haas H S, Schauenstein K. Neuroimmunomodulation via limbic structures - the neuroanatomy of psychoimmunology. Prog Neurobiol. 1997; 51 195-222
- 25 Hocevar A, Tomic M, Praprotnik S, Hojnik M, Kveder T, Rozman B. Parasympathketic nervous system dysfunction in primary Sjögren’s syndrome. Ann Rheum Dis. 2003; 62 702-704
- 26 Hróbjartsson A, Gøtzsche P C. Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment. N Engl J Med. 2001; 344 1594-1602
- 27 Jones T H, Wadler S, Hupart K H. Endocrine-mediated mechanisms of fatigue during treatment with interferon-α. Sem Oncol. 1998; 25 54-63
- 28 Klein R, Berg P A. High incidence of antibodies to 5-Hydroxytryptamine, gangliosides and phosphlipides in patients with chronic fatigue syndrome and their relatives. Evidence for a clinical entity of both disorders. Eur J Med Res. 1995; 1 21-26
- 29 Konsman J P, Parnet P, Dantzer R. Cytokine-induced sickness behaviour: mechanisms and implications. Trends Neurosciences. 2002; 25 154-159
- 30 Libert C. A nervous connection. Nature. 2003; 421 328-329
- 31 Lotti T, Bianchi B, Ghersetich I, Brazzini B, Hercogova J. Can the brain inhibit inflammation generated in the skin? The lesson of α-melanocyte- stimulating hormone. Int J Dermatol. 2002; 41 311-318
- 32 Maeda K, Yasuda M, Kaneda H, Maeda S, Yamadovi A. Cerebrospinal fluid (CFS) neuropeptide (- and somatostatin like immunoreactivities in man. Neuropeptides. 1994; 27 323-332
- 33 Marshall J S, Mc Curdy J D, Olynch T. Toll-like receptor-mediated activation of mast cells: implications for allergic disease?. Int Arch Allergy Immunol. 2003; 132 87-97
- 34 McEwen B S, Alves S H. Estrogen actions in the central nervous system. Endocr Rev. 1999; 20 279-307
- 35 Mönnikes H, Tebbe J J, Hildebrandt M. et al . Role of stress in functional gastrointestinal disorders. Dig Dis. 2001; 19 201-211
- 36 Musselman D L, Lawson D H, Gumnick J F. et al . Paroxetine for the prevention of depression induced by high-interferon alfa. N Engl J Med. 2001; 344 961-966
- 37 Narita M, Nishigami N, Narita N. et al . Association between serotonin transporter gene polymorphism and chronic fatigue syndrome. Biochem Biophys Res Commun. 2003; 311 264-266
- 38 Neumann L, Buskila D. Epidemiology of fibromyalgia. Curr Pain Headache Rep. 2003; 7 362-386
- 39 Nguyen V T, Ndoye A, Grando S G. Novel human a9 acetylcholine receptor regulating keratinocyte adhesion is targeted by pemphigus vulgaris autoimmunity. Am J Pathol. 2000; 157 1377-1391
- 40 Offenbaecher M, Bondy B, de Jonge S. et al . Possible association of fibromyalgia with a polymorphism in the serotonin transporter gene regulatory region. Arthritis Rheum. 1999; 42 2482-2488
- 41 Pavia E S, Deodhar A, Jones K D, Bennett R. Impaired growth hormone secretion in fibromyalgia patients. Arthritis Rheum. 2002; 46 1344-1350
- 42 Roth J, LeRoith D, Shiloach J, Rosenzweig J L, Lesniak M A, Havrankova J. The evolutionary origins of hormones, neurotransmitters, and other extracellular chemical messengers. New Engl J Med. 1982; 306 523-527
- 43 Schauenstein K, Rinner I, Felsner P, Stevenson R, Haas H, Liebmann P. Mens sana in corpore sano - and vice versa. The role of the autonomic nervous system in the immune-neuroendocrine dialogue. Int J Hyg Environ Health. 2001; 204 75-79
- 44 Sherman J J, Turk D C, Okifuji A. Prevalence and impact of posttraumatic stress disorder-like symptoms on patients with fibromyalgia syndrome. Clin J Pain. 2000; 16 127-134
- 45 Spiller R C. Postinfectious irritable bowel syndrome. Gastroenterology. 2003; 124 1662-1671
- 46 Sternberg E M. Neural-immune interactions in health and disease. J Clin Invest. 1997; 100 2641-2647
- 47 Straub R H, Cutolo M. Involvement of the hypothalamic-pituitary-adrenal/gonadal axis and the peripheral nervous system in rheumatoid arthritis. Arthritis Rheum. 2001; 44 493-507
- 48 Suzuki R, Furuno T, McKay D M. et al . Direct neurite-mast cell communication in vitro occurs via the neuropeptide substance P. J Immunol. 1999; 163 2410-2415
- 49 Tanaka S, Matsunaga H, Kimura M. et al . Autoantibodies against four kinds of neurotransmitter receptors in psychiatric disorders. J Neuroimmunol. 2003; 141 155-164
- 50 Tanriverdi F, Silverira L FG, Mac Coll G S, Bouloux P MG. The hypothalamic-pituitary-gonadal axis: immune function and autoimmunity. J Endocrinol. 2003; 176 293-304
- 51 Torpy D J, Bachmann A W, Grice J E. et al . Familial corticosteroid-binding globulin deficiency due to a novel null muttation: association with fatigue and relative hypotension. J Clin Endocrinol Metab. 2001; 86 3692-3700
- 52 Tracey K J. The inflammatory reflex. Nature. 2002; 420 853-859
- 53 Tsigos C, Chrousos G P. Hypothalamic-pituitary-adrenal axis: neuroendocrine factors and stress. J Psychosom Res. 2002; 53 865-871
- 54 Wang H, Yu M, Ochani M. et al . Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation. Nature. 2003; 421 384-388
- 55 Watkins L R, Maier S F. Beyond neurons: Evidence that immune and glial cells contribute to pathological pain states. Physiol Rev. 2002; 82 981-1011
- 56 Yehuda R. Post-traumatic stress disorder. N Engl J Med. 2002; 346 108-114
P. A. Berg
Medizinische Universitätsklinik
Otfried-Müller-Straße 10
72076 Tübingen
Email: peter.a.berg@uni-tuebingen.de