Reactive Hyperaemia in the Forearm Skin of Highly Trained Windsurfers

E. Heylen; B. Simon; F. Guerrero; J.-P. Elkaïm; B. Saïag; J. Mansourati

doi:10.1055/s-2005-837452

International Journal of Sports Medicine, Table of Contents

Int J Sports Med 2005; 26(10): 822-826
DOI: 10.1055/s-2005-837452

Physiology & Biochemistry

Reactive Hyperaemia in the Forearm Skin of Highly Trained Windsurfers

E. Heylen¹ , B. Simon¹ , F. Guerrero¹ , J.-P. Elkaïm² , B. Saïag¹ , J. Mansourati¹ ^, ²

¹E.A. 3879 Unité de Physiologie Comparée et Intégrative, Groupe Endothélium Vasculaire, Exercice, Nutrition et Santé et G.I.S. Sciences du Mouvement, U.F.R. Sport et Education Physique, Brest, France
²Département de Cardiologie, Hôpital de la Cavale Blanche, C.H.U. Brest, France

Abstract

We undertook this study to determine whether long-term high intensity exercise would modify cutaneous endothelial-dependent vasodilation. We compared a group of 9 highly trained windsurfers (mean age: 24.5 ± 1.6 years) to a control group of 8 sedentary individuals (22.9 ± 0.4 years, NS). Laser Doppler was used to measure cutaneous blood flow in the resting state (baseline), during post-occlusive hyperaemia (endothelium-dependent vasodilation), and local heating to 42 °C. Lipid profile was similar in both groups. Resting heart rate was significantly lower in windsurfers. Baseline cutaneous vascular conductance (CVC) values were similar in both groups (0.059 ± 0.016 and 0.051 ± 0.009). During reactive hyperaemia, normalized peak CVC value was significantly higher in the windsurfers group (1775.4 ± 286.9 and 826.4 ± 121.7 % baseline CVC; p = 0.01). Normalized peak CVC value in response to local heating (42 °C) was not significantly different between both groups (2359.4 ± 346.1 and 1467.7 ± 282.6 % baseline CVC). Endothelium-dependent vasodilation in cutaneous microcirculation is significantly enhanced in the forearm skin of highly trained windsurfers when compared to sedentary controls.

Key words

Exercise - laser Doppler - endothelium - vasodilation

Full Text

References

1 Banitt P F, Smits P, Williams S B, Ganz P, Creager M A. Activation of ATP-sensitive potassium channels contributes to reactive hyperemia in humans. Am J Physiol. 1996; 271 1594-1598
2 Beinder E, Schlembach D. Skin flux during reactive hyperemia and local hyperthermia in patients with preeclampsia. Obstet Gynecol. 2001; 98 313-318
3 Binggeli C, Spieker L E, Corti R, Sudano I, Stojanovic V, Hayoz D, Luscher T F, Noll G. Statins enhance postischemic hyperemia in the skin circulation of hypercholesterolemic patients: a monitoring test of endothelial dysfunction for clinical practice?. J Am Coll Cardiol. 2003; 42 71-77
4 Chen H I, Li H T. Physical conditioning can modulate endothelium-dependent vasorelaxation in rabbits. Arterioscler Thromb. 1993; 13 852-856
5 Crandall C G, Shibasaki M, Wilson T E, Cui J, Levine B D. Prolonged head-down tilt exposure reduces maximal cutaneous vasodilator and sweating capacity in humans. J Appl Physiol. 2003; 94 2330-2336
6 Dakak N, Husain S, Mulcahy D, Andrews N P, Panza J A, Waclawiw M, Schenke W, Quyyumi A A. Contribution of nitric oxide to reactive hyperemia: impact of endothelial dysfunction. Hypertension. 1998; 32 9-15
7 Delp M D, McAllister R M, Laughlin M H. Exercise training alters endothelium-dependent vasoreactivity of rat abdominal aorta. J Appl Physiol. 1993; 75 1354-1363
8 Engelke K A, Halliwill J R, Proctor D N, Dietz N M, Joyner M J. Contribution of nitric oxide and prostaglandins to reactive hyperemia in human forearm. J Appl Physiol. 1996; 81 1807-1814
9 Ferguson R A, Brown M D. Arterial blood pressure and forearm vascular conductance responses to sustained and rhythmic isometric exercise and arterial occlusion in trained rock climbers and untrained sedentary subjects. Eur J Appl Physiol. 1997; 76 174-180
10 Fritzsche R G, Coyle E F. Cutaneous blood flow during exercise is higher in endurance-trained humans. J Appl Physiol. 2000; 88 738-744
11 Goto C, Higashi Y, Kimura M, Noma K, Hara K, Nakagawa K, Kawamura M, Chayama K, Yoshizumi M, Nara I. Effect of different intensities of exercise on endothelium-dependent vasodilation in humans: role of endothelium-dependent nitric oxide and oxidative stress. Circulation. 2003; 108 530-535
12 Green D, Cheetham C, Mavaddat L, Watts K, Best M, Taylor R, O'Driscoll G. Effect of lower limb exercise on forearm vascular function: contribution of nitric oxide. Am J Physiol. 2002; 283 899-907
13 Green D J, Fowler D T, O'Driscoll J G, Blanksby B A, Taylor R R. Endothelium-derived nitric oxide activity in forearm vessels of tennis players. J Appl Physiol. 1996; 81 943-948
14 Hambrecht R, Fiehn E, Weigl C, Gielen S, Hamann C, Kaiser R, Yu J, Adams V, Niebauer J, Schuler G. Regular physical exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure. Circulation. 1998; 98 2709-2715
15 Higashi Y, Sasaki S, Kurisu S, Yoshimizu A, Sasaki N, Matsuura H, Kajiyama G, Oshima T. Regular aerobic exercise augments endothelium-dependent vascular relaxation in normotensive as well as hypertensive subjects: role of endothelium-derived nitric oxide. Circulation. 1999; 100 1194-1202
16 Humeau A, Saumet J L, L'Huillier J P. Simplified model of laser Doppler signals during reactive hyperaemia. Med Biol Eng Comput. 2000; 38 80-87
17 Joannides R, Haefeli W E, Linder L, Richard V, Bakkali E H, Thuillez C, Luscher T F. Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation. 1995; 91 1314-1319
18 Johnson J M, Taylor W F, Shepherd A P, Park M K. Laser-Doppler measurement of skin blood flow: comparison with plethysmography. J Appl Physiol. 1984; 56 798-803
19 Kastrup J, Bulow J, Lassen N A. Vasomotion in human skin before and after local heating recorded with laser Doppler flowmetry. A method for induction of vasomotion. Int J Microcirc Clin Exp. 1989; 8 205-215
20 Kingwell B A. Nitric oxide-mediated metabolic regulation during exercise: effects of training in health and cardiovascular disease. Faseb J. 2000; 14 1685-1696
21 Kingwell B A, Sherrard B, Jennings G L, Dart A M. Four weeks of cycle training increases basal production of nitric oxide from the forearm. Am J Physiol. 1997; 272 1070-1077
22 Koller A, Kaley G. Role of endothelium in reactive dilation of skeletal muscle arterioles. Am J Physiol. 1990; 259 1313-1316
23 Kubli S, Waeber B, Dalle-Ave A, Feihl F. Reproducibility of laser Doppler imaging of skin blood flow as a tool to assess endothelial function. J Cardiovasc Pharmacol. 2000; 36 640-648
24 Kvernmo H D, Stefanovska A, Kirkeboen K A, Osterud B, Kvernebo K. Enhanced endothelium-dependent vasodilatation in human skin vasculature induced by physical conditioning. Eur J Appl Physiol. 1998; 79 30-36
25 Lee S M, Williams W J, Schneider S M. Role of skin blood flow and sweating rate in exercise thermoregulation after bed rest. J Appl Physiol. 2002; 92 2026-2034
26 Meredith I T, Currie K E, Anderson T J, Roddy M A, Ganz P, Creager M A. Postischemic vasodilation in human forearm is dependent on endothelium-derived nitric oxide. Am J Physiol. 1996; 270 1435-1440
27 Minson C T, Berry L T, Joyner M J. Nitric oxide and neurally mediated regulation of skin blood flow during local heating. J Appl Physiol. 2001; 91 1619-1626
28 Niebauer J, Cooke J P. Cardiovascular effects of exercise: role of endothelial shear stress. J Am Coll Cardiol. 1996; 28 1652-1660
29 Ninet J, Fronek A. Cutaneous postocclusive reactive hyperemia monitored by laser doppler flux metering and skin temperature. Microvasc Res. 1985; 30 125-132
30 Noon J P, Walker B R, Hand M F, Webb D J. Studies with iontophoretic administration of drugs to human dermal vessels in vivo: cholinergic vasodilatation is mediated by dilator prostanoids rather than nitric oxide. Br J Clin Pharmacol. 1998; 45 545-550
31 O'Sullivan S E. The effects of exercise training on markers of endothelial function in young healthy men. Int J Sports Med. 2003; 24 404-409
32 Rinder M R, Spina R J, Ehsani A A. Enhanced endothelium-dependent vasodilation in older endurance-trained men. J Appl Physiol. 2000; 88 761-766
33 Silber D, McLaughlin D, Sinoway L. Leg exercise conditioning increases peak forearm blood flow. J Appl Physiol. 1991; 71 1568-1573
34 Tagawa T, Imaizumi T, Endo T, Shiramoto M, Harasawa Y, Takeshita A. Role of nitric oxide in reactive hyperemia in human forearm vessels. Circulation. 1994; 90 2285-2290
35 Thomas C M, Pierzga J M, Kenney W L. Aerobic training and cutaneous vasodilation in young and older men. J Appl Physiol. 1999; 86 1676-1686
36 Wong B J, Wilkins B W, Holowatz L A, Minson C T. Nitric oxide synthase inhibition does not alter the reactive hyperemic response in the cutaneous circulation. J Appl Physiol. 2003; 95 504-510
37 Zao J L, Pergola P E, Roman L J, Kellogg Jr D L. Bioactive nitric oxide concentration does not increase during reactive hyperemia in human skin. J Appl Physiol. 2004; 96 628-632

E. Heylen

E. A. 3879 Unité de Physiologie Comparée et Intégrative, U.F.R. Sport et Education Physique

20 avenue Le Gorgeu C.S. 93837

29238 Brest Cedex 3

France

Phone: + 33298016260

Fax: + 33 2 98 01 79 46

Email: erwan.heylen@univ-brest.fr