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Planta Med 2005; 71(2): 191-193
DOI: 10.1055/s-2005-837791
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Combretastatins D-3 and D-4, New Macrocyclic Lactones from Getonia floribunda

Namphung Vongvanich1 , Prasat Kittakoop2 , Panarat Charoenchai2 , Sutichai Intamas2 , Kannawat Danwisetkanjana2 , Yodhathai Thebtaranonth2
  • 1Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand
  • 2National Center for Genetic Engineering and Biotechnology (BIOTEC), NSTDA, Klong Luang, Pathumthani, Thailand
Further Information

Publication History

Received: May 20, 2004

Accepted: September 5, 2004

Publication Date:
24 February 2005 (online)

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Abstract

Chemical investigation of biologically active compounds of Getonia floribunda led to the isolation of two new macrocyclic lactones, combretastatins D-3 (1) and D-4 (2). The structures of these compounds were confirmed by spectroscopic analyses. Combretastatin D-3 (1) exhibited cytotoxicity towards the small-cell lung cancer cell line (NCI-H187, IC50 = 13.0 ± 0.2 μg/mL) but was inactive against KB, BC-1, and Vero cell lines. Combretastatin D-3 (1) showed weak antitubercular activity with a minimum inhibitory concentration (MIC) of 100.0 μg/mL, and was inactive towards the malarial parasite. Combretastatin D-4 (2) was inactive in all antitubercular, antiplasmodial, and cytotoxic assays.

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Dr. Prasat Kittakoop

National Center for Genetic Engineering and Biotechnology

NSTDA

Thailand Science Park

113 Paholyothin Road

Klong 1

Klong Luang

Pathumthani 12120

Thailand

Phone: +662-564-6700 ext. 3560

Fax: +662-564-6707

Email: prasat@biotec.or.th