Mechanisms of Disease:The Biophysical Interpretation of the ECM Affects Physiological and Pathophysiological Cellular Behavior

G. v Wichert; M. P. Sheetz

doi:10.1055/s-2005-858747

Zeitschrift für Gastroenterologie, Table of Contents

Z Gastroenterol 2005; 43(12): 1329-1336
DOI: 10.1055/s-2005-858747

Übersicht

Mechanisms of Disease:The Biophysical Interpretation of the ECM Affects Physiological and Pathophysiological Cellular Behavior

Mechanisms of Disease: Die Interpretation der biophysikalischen Eigenschaften der ECM beeinflusst physiologisches und pathophysiologisches zelluläres VerhaltenG. v. Wichert¹ , M. P. Sheetz²

¹Department of Internal Medicine I, University of Ulm, Germany
²Department of Biological Sciences, Columbia University, New York, USA

Abstract

Zusammenfassung

Physiologische und pathophysiologische Migration während der Organentwicklung oder der systemischen Dissemination von Tumorzellen bedarf einer hochkomplexen Regulation der Interaktion mit der extrazellulären Matrix. Sowohl die Wahrnehmung der physikalischen Eigenschaften der Matrix als auch der Kräfte, die auf die individuelle Zelle einwirken, sind Grundvoraussetzung für produktive Migration. Dieser Übersichtsartikel fasst aktuelle Konzepte der Transmission physikalischer Reize in biochemische Signale in nichtneuronalen Zellen zusammen und analysiert die Bedeutung der Regulation von Affinitätsmodulation und Umsatzraten für die Formation und Funktionalität von Matrixinteraktionen unter besonderer Berücksichtigung onkogener Signalwege wie Src-Familien-Kinasen und der „focal adhesion kinase”.

Abstract

Physiological and pathophysiological migration during the development and systemic spread of tumor cells requires a highly regulated interaction with the extracellular matrix. Sensing of the physical properties of the matrix as well as of forces exerted by the cell or acting on a cell is a prerequisite for productive migration. This review focuses on current concepts of the transmission of a physical stimulus into a biochemical signal in non-neuronal cells. Moreover, we summarize the current concepts on the regulation of affinity-modulation and regulation of protein-turnover for the formation and functionality of adhesion sites with special emphasis on the role of oncogenic signal transduction pathways such as Src family kinases and focal adhesion kinase.

Schlüsselwörter

Migration - Metastasierung - Mechanotransduktion

Key words

Migration - metastatic disease - mechanotransduction

Full Text

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Dr. Götz von Wichert

Abt. Innere Medizin I, Uniklinikum Ulm

Robert-Koch-Str. 8

89081 Ulm

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Email: goetz.wichert@medizin.uni-ulm.de