Zusammenfassung
Synoviale Gelenke sind komplexe Funktionseinheiten, welche uns die Bewegung und Belastung der Extremitäten im dreidimensionalen Raum ermöglichen. Die häufigste Erkrankung der synovialen Gelenke ist die Osteoarthrose, die vor allem durch den fortschreitenden Knorpelschaden gekennzeichnet ist. In dieser Arbeit geben wir einen Überblick über die Physiologie des hyalinen Gelenkknorpels und die verschiedenen pathophysiologischen Modelle seiner Schädigung während des Arthroseprozesses.
Abstract
Synovial joints are highly complex functional units, which allow motion and mechanical loading of upper and lower extremities in the three-dimensional space. Osteoarthritis is the most common joint disease, most prominently characterized by a progressive damage of hyaline cartilage. In this paper, we provide an overview of the physiology of hyaline cartilage and different pathophysiological concepts of cartilage destruction, during the course of osteoarthritis.
Schlüsselwörter
Arthrose - Knorpel - Pathophysiologie
Key words
Osteoarthritis - cartilage - pathophysiology
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Priv.-Doz. Dr. med. David Pfander
Abteilung für Orthopädische Rheumatologie, Orthopädische Klinik mit Poliklinik der Friedrich-Alexander-Universität Erlangen-Nürnberg
Rathsbergerstraße 57
91054 Erlangen
Phone: ++ 49/91 31/82 39 09
Email: DPfander@t-online.de
