Arabinoxylan-enriched Meal Increases Serum Ghrelin Levels in Healthy Humans
M. Möhlig2*, C. Koebnick1*, M. O. Weickert2*, W. Lueder1
, B. Otto3
, J. Steiniger1
, M. Twilfert2
, F. Meuser4
, A. F. H. Pfeiffer2
, H. J. Zunft1
1 Department of Interventional Studies, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
2 Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal and Department of Endocrinology, Diabetes and Nutrition, Campus Benjamin Franklin, Charité-University-Medicine Berlin, Germany
3Medical Department, Innenstadt University Hospital, München, Germany
4Institute of Food Technology and Food Chemistry, Technical University of Berlin, Berlin, Germany
Soluble fibre like arabinoxylan (AX) is thought to have beneficial effects on metabolism. In this study, we investigated the effect of a breakfast enriched in AX fibre on glucose, insulin and ghrelin values. AX-enriched and control breakfasts were served to fifteen young volunteers (nine female, six male). Glucose, insulin and ghrelin responses were measured after the meal. To avoid effects from differences in glucose metabolism, further analysis was restricted to those subjects with known normal glucose regulation (seven female, four male). The AX fibre-enriched breakfast did not significantly change glucose levels for two hours after breakfast, but decreased insulin levels in the entire cohort (p = 0.035). Glucose response was also not significantly different in subjects with normal glucose regulation (p = 0.367), and the insulin responses after an AX-enriched breakfast showed only a tendency towards lower values (p = 0.065). Nevertheless, plasma ghrelin two hours after AX-enriched breakfast was higher than after the control meal (396.1 ± 36.4 pg/ml vs. 328.3 ± 32.6 pg/ml, p < 0.001). In subjects with normal glucose regulation, the AX-enriched breakfast increased ghrelin levels without any significant difference in glucose or insulin response. This effect is therefore unlikely to be mediated by insulin, but the underlying mechanism remains to be elucidated.
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