Catalytic Highly Enantioselective Direct Amination of 1,3-Diketones

Abstract

The direct asymmetric amination of 1,3-diketones by azodicarboxylates catalyzed by chiral copper(II) bisoxazolines is presented. Screening of chiral bisoxazoline ligands, Lewis acids, solvents, and other reaction parameters led to an enantioselective direct amination in the 2-position of 1,3-diketones and the optically active functionalized molecules were obtained in high yields and enantioselectivities.

asymmetric catalysis - 1,3-diketones - aminations - amines - chiral Lewis acids

References

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