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Planta Med 2005; 71(4): 381-384
DOI: 10.1055/s-2005-864111
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Structure Analysis and Antitumor Activity of (1→3)-β-D-Glucans (Cordyglucans) from the Mycelia of Cordyceps sinensis

Wu Yalin1 , Omar Ishurd1 , 2 , Sun Cuirong1 , Pan Yuanjiang1
  • 1Department of Chemistry, Zhejiang University, Hangzhou , P. R. China.
  • 2Bio-technology Research Center, Tripoli, Libya
Further Information

Publication History

Received: June 9, 2004

Accepted: November 15, 2004

Publication Date:
27 April 2005 (online)

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Abstract

The cell wall polysaccharides from Cordyceps sinensis were obtained from the fresh samples of the mycelia, the material was released by successive extractions with hot water and 0.05 M sodium hydroxide solutions. The extracts were fractionated by ion-exchange and gel-filtration chromatography, respectively. Analysis of the first fraction showed that cordyglucans were the unique component. Cordyglucans were found to exhibit potent antitumor activity, this activity could be correlated to their (1→3)-β-D-glucan linkages.

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Prof. Dr. Pan Yuanjiang

Department of Chemistry

Zhejiang University

YuQuan Campus

Hangzhou 310027

People’s Republic of China

Phone: +86-571-8795-1264

Fax: +86-571-8795-1264

Email: panyuanjiang01@yahoo.com