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Planta Med 2005; 71(5): 470-475
DOI: 10.1055/s-2005-864144
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag KG Stuttgart · New York

New Indolopyridoquinazoline, Benzo[c]phenanthridines and Cytotoxic Constituents from Zanthoxylum integrifoliolum

Jih-Jung Chen1 , Hui-Yu Fang1 , Chang-Yih Duh2 , Ih-Sheng Chen3
  • 1Graduate Institute of Pharmaceutical Technology, Tajen Institute of Technology, Pingtung, Taiwan, R.O.C.
  • 2Institute of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, R.O.C.
  • 3School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.
Further Information

Publication History

Received: July 7, 2004

Accepted: November 16, 2004

Publication Date:
01 June 2005 (online)

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Abstract

Three new alkaloids, 7,8-dehydro-1-methoxyrutaecarpine, isodecarine, and 8-demethyloxychelerythrine, together with sixteen known compounds, norchelerythrine, oxychelerythrine, decarine, dihydrocherythrinylacetaldehyde, 6-acetonyldihydrochelerythrine, rutaecarpine, 1-hydroxyrutaecarpine, γ-fagarine, skimmianine, (-)-matairesinol, (-)-isoarctigenin, (+)-epipinoresinol, d-sesamin, lupeol, canthin-6-one, and arnottianamide have been isolated from the root bark of Zanthoxylum integrifoliolum. The structures of these new compounds were determined through spectral analyses. Among the isolates, 7,8-dehydro-1-methoxyrutaecarpine, norchelerythrine, oxychelerythrine, dihydrocherythrinylacetaldehyde, 6-acetonyldihydrochelerythrine, 1-hydroxyrutaecarpine, γ-fagarine, skimmianine, (-)-matairesinol, and canthin-6-one exhibited cytotoxicities (ED50 values < 4 μg/mL) against P-388 or HT-29 cell lines in vitro.

Key words

Zanthoxylum integrifoliolum - Rutaceae - root bark - 7,8-dehydro-1-methoxyrutaecarpine - isodecarine - 8-demethyloxychelerythrine - cytotoxicity

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Dr. J. J. Chen

Department of Pharmacy

Tajen Institute of Technology

Pingtung

Taiwan 907

R.O.C.

Fax: +886-8-762-5308

Email: jjchen@ccsun.tajen.edu.tw