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Dtsch Med Wochenschr 2005; 130(13): 809-811
DOI: 10.1055/s-2005-865093
DOI: 10.1055/s-2005-865093
Prinzip & Perspektive
Gastroenterologie/Onkologie
© Georg Thieme Verlag Stuttgart · New York
Kolonkarzinom: Molekulare Pathogenese und klinische Relevanz
Colon cancer: molecular pathogenesis and clinical relevanceFurther Information
Publication History
eingereicht: 11.10.2004
akzeptiert: 18.2.2005
Publication Date:
24 March 2005 (online)
Glossar
CRC = kolorektales Karzinom
CIN = chromosomale Instabilität
CIMP = CpG-Insel-Methylierungsphänotyp
MSI = Mikrosatelliteninstabilität
Literatur
- 1 Arnold C, Usadel H, Blum H E. Epigenetics: significance for tumor genesis and clinical features. Dtsch Med Wochenschr. 2002; 127 1701-1703
- 2 Goel A, Arnold C N, Niedzwiecki D. et al . Characterization of sporadic colon cancer by patterns of genomic instability. Cancer Res. 2003; 63 1608-1614
- 3 Ionov Y, Peinado M A, Malkhosyan S. et al . Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature. 1993; 363 558-561
- 4 Toyota M, Ahuja N, Ohe-Toyota M. et al . CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci USA. 1999; 96 8681-8686
- 5 Vogelstein B, Fearon E R, Hamilton S R. et al . Genetic alterations during colorectal-tumor development. N Engl J Med. 1988; 319 525-532
Dr. med. Christian N. Arnold
Medizinische Universitätsklinik Freiburg, Abteilung Innere Medizin II
Hugstetter Straße 55
79106 Freiburg
Phone: 0761/2703401
Fax: 0761/2703655
Email: arnold@med1.ukl.uni-freiburg.de