Abstract
Analogs of naturally occurring furanones that were reported to be weak inhibitors
of Serratia marcescens chitinases were prepared and tested towards various chitinases. Some of these compounds
- but not the natural products - were found to be weak but selective inhibitors; all
glycosylated analogs tested were inactive. Activation of the plant enzyme hevamine
was observed in one case, which is unusual.
Key words
chitinases - enzyme inhibitors - furan-2(5H )-ones - glycosylation - hevamine activation
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