Chiral Succinate: A Precursor for Enantiomerically Pure β2-Amino Acids

Arvydas Stončius; Markus Nahrwold; Norbert Sewald

doi:10.1055/s-2005-865362

PAPER

Chiral Succinate: A Precursor for Enantiomerically Pure β²-Amino Acids

Arvydas Stončius, Markus Nahrwold, Norbert Sewald*
Bielefeld University, Department of Chemistry, Universitätsstr. 25, 33615 Bielefeld, Germany
Fax: +49(521)1068094; e-Mail: norbert.sewald@uni-bielefeld.de;

Abstract

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Abstract

Five suitably protected enantiomerically pure β²-amino acids, homologues of proteinogenic α-amino acids, were synthesized from the common chiral precursor, tert-butyl succinyloxazolidinone.

Key words

β-amino acids - rearrangements - regioselectivity - ring closure - stereoselective synthesis

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References

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Part of this work was presented in the conferences:

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It was later confirmed by mass spectrometry of crude product: signals corresponding to double alkylation products were observed in MS (ESI).

Manuscript in preparation.

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