Efficient Synthesis of N-Protected Trisubstituted Oxazolidines from Ketones, Vinyl Ethers, and Fluoroalkanesulfonyl Azides in Mild Conditions

Abstract

A facile one-step method has been developed for the synthesis of 2,3,5-trisubstituted oxazolidines in moderate yields by the three-component reaction of ketones, vinyl ethers, and fluoroalkanesulfonyl azides at 0 °C within five minutes. This practical synthetic method provides a convenient and expeditious access to N-per(poly)fluoroalkanesulfonyl oxazolidines.

Key words

fluoroalkanesulfonyl azide - ketone - vinyl ether - oxazolidine - multi-component reactions

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He, P.; Zhu, S. Z. Tetrahedron 2005, in press.

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CCDC number: CCDC 262795