Palladium-Phosphinous Acid Catalyzed Cross-Coupling of Aryl Halides Using a Hypervalent Phenylsilane in Water

Rachel Lerebours; Christian Wolf

doi:10.1055/s-2005-870013

PAPER

Palladium-Phosphinous Acid Catalyzed Cross-Coupling of Aryl Halides Using a Hypervalent Phenylsilane in Water

Rachel Lerebours, Christian Wolf*
Department of Chemistry, Georgetown University, Washington, DC 20057, USA
Fax: +1(202)6876209; e-Mail: cw27@georgetown.edu;

Abstract

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Abstract

A palladium-phosphinous acid catalyzed NaOH-promoted cross-coupling methodology that affords biaryls from tetrabutylammonium triphenyldifluorosilicate and aryl halides in good to high yields has been developed. The coupling proceeds in aqueous 0.5 M NaOH solution in the absence of organic co-solvents and does not require inert atmosphere, which greatly facilitates operation and catalyst handling.

Key words

biaryls - cross-coupling - silicon - palladium - catalysis

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References

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