Anti-Babesial Compounds from Curcuma zedoaria

Ken Kasahara; Shinkichi Nomura; null Subeki; Hideyuki Matsuura; Masahiro Yamasaki; Osamu Yamato; Yoshimitsu Maede; Ken Katakura; Mamoru Suzuki; null Trimurningsih; null Chairul; Teruhiko Yoshihara

doi:10.1055/s-2005-871216

Planta Med 2005; 71(5): 482-484
DOI: 10.1055/s-2005-871216

Letter

Anti-Babesial Compounds from Curcuma zedoaria

Ken Kasahara¹ , Shinkichi Nomura¹ , Subeki¹ , Hideyuki Matsuura¹ , Masahiro Yamasaki² , Osamu Yamato² , Yoshimitsu Maede² , Ken Katakura³ , Mamoru Suzuki³ , Trimurningsih⁴ , Chairul⁴ , Teruhiko Yoshihara¹

¹Laboratory of Bioorganic Chemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
²Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
³Department of Parasitology, Gunma University School of Medicine, Maebashi, Japan
⁴Research and Development for Biology, Indonesian Institute of Sciences, Bogor, Indonesia

Abstract

Anti-babesial activity was confirmed in an extract of the bark of Curcuma zedoaria. The active ingredients were isolated, and their chemical structures were determined to be zedoalactones A, B, and C based on spectral data. Zedoalactone C is a hitherto unreported compound. The IC₅₀ vales of these active compounds against Babesia gibsoni were compared with a standard drug, diminazene aceturate. The IC₅₀ value of diminazene aceturate was 0.6 μg/mL, while those of zedoalactones A, B, and C were 16.5, 1.6 and 4.2 μg/mL, respectively.

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References

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Hideyuki Matsuura

Laboratory of Bioorganic Chemistry

Division of Applied Bioscience

Graduate School of Agriculture

Hokkaido University

Sapporo 060-8589

Japan

Phone: +81-11-706-2495

Fax: +81-11-706-2505

Email: matsuura@chem.agr.hokudai.ac.jp