Diterpene Glycosides from Egletes viscosa

Dongho Lee; Chen Li; Tyler N. Graf; Jose Schunke Vigo; James G. Graham; Fernando Cabieses; Norman R. Farnsworth; Geoffrey A. Cordell; A. Douglas Kinghorn; David J. Kroll; Mansukh C. Wani; Nicholas H. Oberlies

doi:10.1055/s-2005-871227

Planta Med 2005; 71(8): 792-794
DOI: 10.1055/s-2005-871227

Letter

Diterpene Glycosides from Egletes viscosa

Dongho Lee¹ ^, ⁴ , Chen Li¹ , Tyler N. Graf¹ , Jose Schunke Vigo² , James G. Graham³ ^, ⁵ , Fernando Cabieses² , Norman R. Farnsworth³ , Geoffrey A. Cordell³ , A. Douglas Kinghorn³ ^, ⁶ , David J. Kroll¹ , Mansukh C. Wani¹ , Nicholas H. Oberlies¹

¹Natural Products Laboratory, Research Triangle Institute, Research Triangle Park, North Carolina, USA
²Instituto Nacional de Medicina Tradicional (INMETRA), Minesterio de Salud, Jesus Maria, Lima, Peru
³Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA
⁴Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea
⁵Center for Ethnobiology and Natural Products, Florida International University, University Park Campus, Miami, Florida, USA
⁶Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA

Abstract

A phytochemical investigation of the CHCl₃-soluble extract of the entire plant of Egletes viscosa (Asteraceae), collected in Peru, afforded two new labdane glycosides, 13-hydroxy-7-oxolabda-8,14-diene 13(R)-O-α-L-arabinopyranoside and 13-hydroxylabda-7,14-diene 13(R)-O-α-L-arabinopyranoside, along with four known compounds. The structures of the new compounds were elucidated by spectroscopic and chemical methods.

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Nicholas H. Oberlies

Natural Products Laboratory

Research Triangle Institute

P.O. Box 12194

Research Triangle Park

North Carolina 27709

USA

Fax: +1-919-541-6499

eMail: oberlies@rti.org